DRSC/TRiP Functional Genomics Resources

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Protein Alignment TIAL1 and CstF64

DIOPT Version :10

Sequence 1:NP_001029097.1 Gene:TIAL1 / 7073 HGNCID:11804 Length:392 Species:Homo sapiens
Sequence 2:NP_477453.1 Gene:CstF64 / 42239 FlyBaseID:FBgn0027841 Length:419 Species:Drosophila melanogaster


Alignment Length:353 Identity:78/353 - (22%)
Similarity:125/353 - (35%) Gaps:105/353 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   116 VFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWL 180
            ||||::..|.|.|.:|..|:..|.:...::|.|..:||.||:||..:.::..|.:|:.::.|..:
  Fly    18 VFVGNIPYEATEEKLKEIFSEVGPVLSLKLVFDRESGKPKGFGFCEYKDQETALSAMRNLNGYEI 82

Human   181 GGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVN--------QSSPKNCTVYCGGIASGLTDQL 237
            |||.:|.:.|..:    ||..|.. :.|:...|.|        :.:|:..|.....:......:|
  Fly    83 GGRTLRVDNACTE----KSRMEMQ-QLLQGPQVENPYGEPCEPEDAPELITKTVASLPPEQMYEL 142

Human   238 MRQ-----TFSPFGQIMEIRVFPEKGYSF------VRFSTHESAAHAIVSVN-------GTTIEG 284
            |:|     ..:|......:.:.|:..|:.      :|....:.|...:...|       |...:|
  Fly   143 MKQMKLCIVSNPSEARQMLMLNPQLAYALLQAMVVMRIVDPQQALGMLFKANQMPPVLGGNPHQG 207

Human   285 HVVKCYWGKESPDMTKNFQQVDYSQWGQW--------------SQVYGN---------------P 320
            .......|::....    |||...|..|.              :.|:.|               |
  Fly   208 PGNHTMMGQQQVPQ----QQVQIPQQQQQAPQPPMPVPGPGFPANVHPNDIDLRMVPGGPMPMDP 268

Human   321 QQYGQYMANGW-------------------QVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQP 366
            :..|:.|....                   |:||         ||..||.|:|.|.:......:|
  Fly   269 RMMGRGMDQDLRASLPNPVPPPLMDPRARAQMPP---------QQQQGVPQAPPAPYPSDPRQRP 324

Human   367 ----------PQGQAPP---PVIPPPNQ 381
                      ||.||||   |..|||.|
  Fly   325 MDPRLRAGPGPQQQAPPQGIPQAPPPTQ 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TIAL1NP_001029097.1 RRM1_TIAR 10..107 CDD:410028
RRM2_TIAR 113..192 CDD:410029 26/75 (35%)
RRM3_TIAR 222..294 CDD:241064 13/89 (15%)
CstF64NP_477453.1 RRM_CSTF2_CSTF2T 10..94 CDD:410072 26/75 (35%)
CSTF2_hinge 111..190 CDD:433869 11/78 (14%)
CSTF_C 377..416 CDD:464130
Blue background indicates that the domain is not in the aligned region.

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