DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TIAL1 and tial1

DIOPT Version :9

Sequence 1:	NP_001029097.1	Gene:	TIAL1 / 7073	HGNCID:	11804	Length:	392	Species:	Homo sapiens
Sequence 2:	XP_005156854.1	Gene:	tial1 / 394107	ZFINID:	ZDB-GENE-040426-1547	Length:	399	Species:	Danio rerio

Alignment Length:	403	Identity:	335/403 - (83%)
Similarity:	362/403 - (89%)	Gaps:	16/403 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     2 MEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPD-SRRVN-SSVGFSVLQHTSN 64
            |||:..|:|||||||||||||.||||||:||||||||||||||.| ||::| ||:||||||||||
Zfish     1 MEDESHPKTLYVGNLSRDVTENLILQLFTQIGPCKSCKMITEQSDSSRKMNSSSIGFSVLQHTSN 65

Human    65 DPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTED 129
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Zfish    66 DPYCFVEFFEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTDD 130

Human   130 IKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKL----------DAENAIVHMGGQWLGGRQ 184
            |::|||||||||||||||||.||||||||||||||||          ||||||||||||||||||
Zfish   131 IRAAFAPFGKISDARVVKDMTTGKSKGYGFVSFYNKLVRLQYRNRVKDAENAIVHMGGQWLGGRQ 195

Human   185 IRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIM 249
            |||||||||||||||.|:|:.|||||::|||||||:|||||||||.||||:.|||||||||||||
Zfish   196 IRTNWATRKPPAPKSVQDNSAKQLRFDEVVNQSSPQNCTVYCGGIQSGLTEHLMRQTFSPFGQIM 260

Human   250 EIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWS 314
            ||||||||||||:|||:||||||||||||||||||||||||||||||||.||.|.::|.|||||:
Zfish   261 EIRVFPEKGYSFIRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMAKNVQPMEYGQWGQWN 325

Human   315 QVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPP 379
            |:|||||||||||.||||||.||:|||.||||||||:||.|.||:||||.||.|.| |..|:
Zfish   326 QMYGNPQQYGQYMTNGWQVPSYGMYGQTWNQQGFGVEQSQSPAWVGGFGTQPSQAQ-PGAVM--- 386

Human   380 NQAGYGMASYQTQ 392
            |||.:|||.||||
Zfish   387 NQANFGMAGYQTQ 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	89/98 (91%)
		RRM2_TIAR	113..192	CDD:410029	74/88 (84%)
		RRM3_TIAR	222..294	CDD:241064	66/71 (93%)
tial1	XP_005156854.1	RRM	7..295	CDD:223796	251/287 (87%)
		RRM_SF	9..108	CDD:302621	89/98 (91%)
		RRM2_TIAR	114..203	CDD:241061	74/88 (84%)
		RRM3_TIAR	233..305	CDD:241064	66/71 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I15512
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H87796
Inparanoid	1	1.050	683	1.000	Inparanoid score	I4437
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53065
OrthoDB	1	1.010	-	-		D1066369at2759
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	1	1.000	-	-		oto45020
orthoMCL	1	0.900	-	-		OOG6_103013
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1842
SonicParanoid	1	1.000	-	-		X831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.370