Protein Alignment TIAL1 and tiar-2

DIOPT Version :9

• Sequence 1: NP_001029097.1
• Gene: TIAL1 / 7073
• HGNCID: 11804
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_496718.1
• Gene: tiar-2 / 174909
• WormBaseID: WBGene00012904
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 423
• Identity: 155/423 - (36%)
• Similarity: 206/423 - (48%)
• Gaps: 82/423 - (19%)

Human     8 PRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEF 72
            ||||:|.||...:|:..:..||:|||.....|:|.|           |.       ||||.||||
 Worm    39 PRTLFVANLDPAITDEFLATLFNQIGAVMKAKIIFE-----------GL-------NDPYAFVEF 85

Human    73 YEHRDAAAALAAMNGRKILGKEVKVNWATTP-----SSQKKDTSNHFHVFVGDLSPEITTEDIKS 132
            .:|..|..||.:.|||::|.||:.|.||..|     :..|.:||.|||||||||..||.:..::.
 Worm    86 SDHNQATLALQSHNGRELLEKEMHVTWAFEPREPGENRSKPETSRHFHVFVGDLCSEIDSTKLRE 150

Human   133 AFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP 197
            ||..||::|:|::::|..|.|.|||||||:..:.|||.||..|.|.|||.|.||||||||||...
 Worm   151 AFVKFGEVSEAKIIRDNNTNKGKGYGFVSYPRREDAERAIDEMNGAWLGRRTIRTNWATRKPDED 215

Human   198 KS----------------TQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFG 246
            ..                .:.:|..:..::::.||::..|.:||.|.||: |.:..:|:.|..||
 Worm   216 GERGGDRGDRRGGGGGGRDRYHNQSEKTYDEIFNQAAADNTSVYVGNIAN-LGEDEIRRAFDRFG 279

Human   247 QIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWG 311
            .|.|:|.|..:||:||:|.|.||||.|||.:|...|.|.:|:|.||| |.|..|..::......|
 Worm   280 PINEVRTFKIQGYAFVKFETKESAARAIVQMNNADIGGQIVRCSWGK-SGDSGKPSERGSGGGGG 343

Human   312 QWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGA------------ 364
            ..:..||    ||.....|..       |.|.|.|....:|.|..:..||.|.
 Worm   344 SGNYGYG----YGNSGGGGGS-------GGPGNSQFSNFNQRPPPSGNGGSGGGSGGQNNQYWQY 397

Human   365 ------QPP---------QGQAPPPVIPPPNQA 382
                  .|.         |...||   |||..|
 Worm   398 YSQYYNNPHLMQQWNNYWQKDGPP---PPPAAA 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TIAL1	NP_001029097.1	RRM1_TIAR	10..107	CDD:410028	37/101 (37%)
		RRM2_TIAR	113..192	CDD:410029	44/78 (56%)
		RRM3_TIAR	222..294	CDD:241064	34/71 (48%)
tiar-2	NP_496718.1	RRM	36..321	CDD:223796	124/300 (41%)
		RRM_SF	42..113	CDD:302621	33/88 (38%)
		RRM_SF	133..207	CDD:302621	39/73 (53%)
		RRM3_TIA1_like	256..326	CDD:240800	33/70 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I5349
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2034
Isobase	1	0.950	-	0	Normalized mean entropy	S1737
OMA	1	1.010	-	-		QHG53065
OrthoDB	1	1.010	-	-		D1066369at2759
OrthoFinder	1	1.000	-	-		FOG0000924
OrthoInspector	1	1.000	-	-		mtm4993
orthoMCL	1	0.900	-	-		OOG6_103013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690