DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KLF10 and btd

DIOPT Version :9

Sequence 1:NP_005646.1 Gene:KLF10 / 7071 HGNCID:11810 Length:480 Species:Homo sapiens
Sequence 2:NP_511100.1 Gene:btd / 31912 FlyBaseID:FBgn0000233 Length:644 Species:Drosophila melanogaster


Alignment Length:462 Identity:115/462 - (24%)
Similarity:173/462 - (37%) Gaps:128/462 - (27%)


- Green bases have known domain annotations that are detailed below.


Human     9 QQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEALMSM------SCSWKSDFKKYVENRP--- 64
            ||..:::.:...::|::         ::.||.:..||:|.      |.|..|.....:..:|   
  Fly    71 QQQQQQQQQQQQQQPQQ---------QQHDFLSAAALLSAPPSLSGSSSGSSSGSSPLYGKPPMK 126

Human    65 -VTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDF-EPSQVSNLMAPAPSTVHFKSLSDTAK 127
             ..|....|......|.: ...:.|:   :...|||.| .|:|....::.:|||.     :.|..
  Fly   127 LELPYPQASSTGTASPNS-SIQSAPS---SASVSPSIFPSPAQSFASISASPSTP-----TTTLA 182

Human   128 PHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILN--YQNNSFRRRTH 190
            |...|.......||.|:.  |.:.|.|.....|.|...   ...:.||::.:  |..|:    .:
  Fly   183 PPTTAAAGALAGSPTSSS--PSSSAASAAAAAAAAAAA---AADLGAAAVASAAYGWNT----AY 238

Human   191 LNVEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSV 255
            ..:..||...|.|                   :.::..|..:|..|      |..|..|.|::  
  Fly   239 SGLGPARSQFPYA-------------------QYASDYYGNAVGMS------SSAAWFSHQER-- 276

Human   256 LVSPPAVSAGGVPPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFV 320
                                            ...|.:..|.|......:.|. ||:.:.:|...
  Fly   277 --------------------------------LYQPWSSQSYPGFNFDDIAFQ-TQLQRRSVRCT 308

Human   321 VPQPVVQ-SSKPPVVSPNGTRLSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSS 384
            .|....: |..||:|.|                         |....:.|||..|||.:.|.|:|
  Fly   309 CPNCTNEMSGLPPIVGP-------------------------DERGRKQHICHIPGCERLYGKAS 348

Human   385 HLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHAR 449
            |||.|.|.||||:||.|  ..|.:||:|||||.||.||||..:.:|||:|.::|.|||||:||.:
  Fly   349 HLKTHLRWHTGERPFLC--LTCGKRFSRSDELQRHGRTHTNYRPYACPICSKKFSRSDHLSKHKK 411

Human   450 RHLSAKK 456
            .|...||
  Fly   412 THFKDKK 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KLF10NP_005646.1 zf-C2H2 369..393 CDD:278523 14/23 (61%)
COG5048 374..>424 CDD:227381 30/49 (61%)
C2H2 Zn finger 374..393 CDD:275368 11/18 (61%)
zf-H2C2_2 385..412 CDD:290200 15/26 (58%)
C2H2 Zn finger 401..423 CDD:275368 12/21 (57%)
zf-H2C2_2 415..438 CDD:290200 12/22 (55%)
zf-C2H2 429..451 CDD:278523 12/21 (57%)
C2H2 Zn finger 431..451 CDD:275368 11/19 (58%)
btdNP_511100.1 C2H2 Zn finger 338..357 CDD:275368 11/18 (61%)
zf-H2C2_2 349..374 CDD:290200 15/26 (58%)
C2H2 Zn finger 365..385 CDD:275368 12/21 (57%)
zf-H2C2_2 377..402 CDD:290200 13/24 (54%)
zf-C2H2 391..413 CDD:278523 12/21 (57%)
C2H2 Zn finger 393..413 CDD:275368 11/19 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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