DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik3 and par-1

DIOPT Version :9

Sequence 1:NP_081774.3 Gene:Sik3 / 70661 MGIID:2446296 Length:1369 Species:Mus musculus
Sequence 2:NP_995894.2 Gene:par-1 / 2768852 FlyBaseID:FBgn0260934 Length:1170 Species:Drosophila melanogaster


Alignment Length:1033 Identity:317/1033 - (30%)
Similarity:456/1033 - (44%) Gaps:223/1033 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse    16 GAGGAGPAGR-LLPPPAAGPPAAPAAVPPAA----VPARPTAPASRGSMAARIGYYEIDRTIGKG 75
            |:|.|....: :|...:|.|.|.......|.    :..|.:||....:....||.|::.:|||||
  Fly   198 GSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKG 262

Mouse    76 NFAVVKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 140
            |||.||.|.||.|..:||||||||:||:..:|:|:||||:|||||.||:|::|:||:|||:.:||
  Fly   263 NFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYL 327

Mouse   141 VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 205
            :.|||||||:||:||.||||.|||||.||:|||:||.:||.:.|:||||||||||||:.||||||
  Fly   328 IMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIA 392

Mouse   206 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 270
            ||||||.||||..|.|:||||||||||||:||:||||:||:|||||:||.||.|:||||||||:.
  Fly   393 DFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRE 457

Mouse   271 LRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQ 335
            ||.|||.||:||||:|||:||:|:|..|||:|.||.|:|.|...|||.:|..:......|.....
  Fly   458 LRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKAD 522

Mouse   336 LKEERQSDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTLRPGALPSM 400
            |     :||...:.|:|   ||.::.....||....||...|.|.||            |...:.
  Fly   523 L-----ADPKRIEALVA---MGYNRSEIEASLSQVRYDDVFATYLLL------------GRKSTD 567

Mouse   401 PQAMTFQAPVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVNLDSDEGEEPSPEALVRYLS- 464
            |::         ...::|::::|           ..|...|...|..|...:.|:...:.|.:| 
  Fly   568 PES---------DGSRSGSSLSL-----------RNISGNDAGANAGSASVQSPTHRGVHRSISA 612

Mouse   465 -----MRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNFTHNLLPMQSLQPTGQL 524
                 .||.:.||..  |.....:.........|||..       |.|...:.....|:..    
  Fly   613 SSTKPSRRASSGVGP--TNAAATVAAATGAVGAVNPSN-------NYNAAGSAADRASVGS---- 664

Mouse   525 EYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMT-------PAVP 582
            .:|.|:.:...|::               ....:|.||.  :||...:..:..|       ||.|
  Fly   665 NFKRQNTIDSATIK---------------ENTARLAAQN--QRPASATQKMLTTADTTLNSPAKP 712

Mouse   583 AVTPVDEESSDGEPDQEAVQRYLANRSKRHTL----AMTSPTAEIPPD---LQRQLGQQSFRSRV 640
            . |....:.::|..........:..||.  ||    :.|..|..||.:   ..|.....:.:|..
  Fly   713 R-TATKYDPTNGNRTVSGTSGIIPRRST--TLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSR 774

Mouse   641 WPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNSSSIK-------- 697
            ..|..||.  |||:....|    ..|.:....:| |.:......:|..:|...|.:.        
  Fly   775 HFPRNVPS--RSTFHSGQT----RARNNTALEYS-GTSGASGDSSHPGRMSFFSKLSSRFSKRPT 832

Mouse   698 -----------QLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQH------------HQILQ 739
                       :.....:....:...|:.::..|...|.:..|:|.:.            ..::|
  Fly   833 IADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQ 897

Mouse   740 QQIQDSICPPQPSPPLQVACENQPALLTHQLQRLRIQPSSPPPNHPSNHL-------FRQPSNSP 797
            .:|:  :|             ..|.|..:.::..||..:|....:.::.:       ..|.:|. 
  Fly   898 WEIE--VC-------------KLPRLSLNGVRFKRISGTSIGFKNIASRIAFDLKLXLNQTNNE- 946

Mouse   798 PPVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPPPS--------VALTCLGL--QQASQS 852
               .:|..|:...|.|:.           .....||..|.:        ::|.|..|  ||.||.
  Fly   947 ---GNAAATASRPTDPTD-----------TMTTTNCRRPSNDSTSRLSELSLLCRSLTSQQGSQR 997

Mouse   853 QPVTIQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLMA-----PFSYGHRPLSKQ 912
            :                         :...:|...|:.|.:..:.|.|     |||      ||:
  Fly   998 R-------------------------KKSRLSTGGSEDQKKSNSLLSAFQMYSPFS------SKE 1031

Mouse   913 LSADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFPPTQALKV 970
            ....|.|...|::....|.:    .:...||:|.|..:|.....:.||....|...||
  Fly  1032 NMQSSEEVEDLHVIDTQPGH----SVDVPLFADFSPINPIMEEDAEGVEGGKTSEAKV 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_081774.3 STKc_SIK 65..317 CDD:270973 173/251 (69%)
S_TKc 66..317 CDD:214567 173/250 (69%)
UBA_SIK3 346..390 CDD:270593 12/43 (28%)
par-1NP_995894.2 STKc_MARK 252..504 CDD:270974 173/251 (69%)
S_TKc 253..504 CDD:214567 173/250 (69%)
UBA_MARK_Par1 525..563 CDD:270522 14/52 (27%)
MARK1-3_C 839..936 CDD:213381 13/111 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5061
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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