DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THBS4 and cubn-1

DIOPT Version :9

Sequence 1:	NP_003239.2	Gene:	THBS4 / 7060	HGNCID:	11788	Length:	961	Species:	Homo sapiens
Sequence 2:	NP_506157.3	Gene:	cubn-1 / 179729	WormBaseID:	WBGene00013855	Length:	4047	Species:	Caenorhabditis elegans

Alignment Length:	644	Identity:	142/644 - (22%)
Similarity:	221/644 - (34%)	Gaps:	207/644 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    66 LQTKSSATIFGLYSSTDNSKYFE------FTVMGRLNKAILRYLKNDGKVHLVVFNNLQLADGRR 124
            ||...|..:|||.:...:..|.|      :....|:               |:|..|:.|..|:.
Worm     5 LQLFLSLILFGLLNHVSSIDYEEIHIEDSYETRSRI---------------LMVDGNVWLHAGKD 54

Human   125 HRILLRLSNLQRGAGSLELYLDCIQVDSVHNLPRAFAGPSQKPETIELRTFQRKPQDF-LEELKL 188
            ..|..:.:      |:..:|:|...|..:.::........:...|.::.|..:..||. ...:::
Worm    55 KNITFKTT------GNGRIYVDETDVSKLPDIASFKQLVGRIENTSQMFTTLKSRQDTQTSAMRV 113

Human   189 VVRGSLFQVASLQDCFLQ-------QSEPLAATGTGDFNRQ-FLGQMTQLNQLLGEVKDLLRQQV 245
            |:..:...:.:|::..|:       :::.:|.    |..|: .|.:||:  |::|
Worm   114 VLNSAKHYLVALRNMTLEVNILKKWKTDKMAR----DMRRRGLLVKMTR--QIIG---------- 162

Human   246 KETSFLRNTIAECQACGPLKFQSPTPSTVVPPAPP-----APPTRPPRRCDSN------------ 293
                  .|.:....||.|.|..:  ..|.:|....     .||......|:::
Worm   163 ------INKLIAINACDPNKCSN--GGTCIPSFGAKFTCLCPPHFTGTTCEADIDECSVYNGTTA 219

Human   294 PCFRGVQCTDSRDGFQCGPCPEGYTG--------------------------------------- 319
            .|.....|.::|.||:| .|..||.|
Worm   220 GCQNNGTCINNRGGFEC-QCQSGYHGSLCQYHMSACSKTFELCGPHGHCIESIVDPTGQSSSDTT 283

Human   320 ----------------NGITCIDVDECKYHPCYPGVHCINLSPGFRCDACPVGFTGPMVQGVGIS 368
                            |..||:||:||:.:||:|||.||||...|.|..||.|:
Worm   284 TYKCICDWGFKVSSDKNNPTCVDVNECESNPCHPGVDCINLPGSFVCSGCPKGY----------- 337

Human   369 FAKSNKQVCTDIDECRN--GACVPNSICVNTLGSYRCGPCKPGYTGDQIRGCKAERNCRNPELNP 431
              |::..||.|::||..  ..|.|.|.|.||||||.|..|..||:||. ..|..:.:|..   |.
Worm   338 --KTDGNVCIDVNECEGEIRVCSPLSKCHNTLGSYYCDSCPTGYSGDG-GNCVKDDSCVK---NK 396

Human   432 CSVNAQCI-----EERQGDVTCVCGVGWAGDGY-----------IC--------GK-----DVD- 466
            |...|.|.     ....||.||.|..|:.|||.           :|        ||     |.:
Worm   397 CHKLATCKVTDDGYSAVGDYTCYCPDGYVGDGIGEEGCVKSASNVCQNHNCVNAGKCKPTSDTEY 461

Human   467 --------IDSYPDEELPCSARNCKK-DNCKYVPNSGQEDADRDGIGDACDEDAD--GDGILNEQ 520
                    :..:.::..||....||. ..|..|.||...|......|.||:|:.:  |....:..
Worm   462 KCECEAGFLGKFCEKTSPCQTNPCKNGGTCIAVENSAYCDCPEHFFGRACEEEEEHCGSHFTHSS 526

Human   521 DNCVLIHNVDQRNSDKD-------IFGDACDNCLSVLNNDQKD---TDGDGRGDACDDD 569
            .|    :..|.:.|:|.       :|.....|...|:...:.|   .:|.|..|....|
Worm   527 GN----YTFDLQRSNKTELSICDFVFNIPAANSAVVMTFTEFDKFTQEGSGPTDCAKTD 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THBS4	NP_003239.2	TSPN	24..192	CDD:214560	24/132 (18%)
		coiled coil	219..262	CDD:293926	8/43 (19%)
		TSP-4cc	219..262	CDD:293926	8/43 (19%)
		EGF	290..320	CDD:278437	11/96 (11%)
		EGF_CA	326..360	CDD:238011	18/33 (55%)
		EGF_CA	379..413	CDD:238011	17/35 (49%)
		TSP type-3 1	463..495		10/46 (22%)
		TSP type-3 2	496..531		7/36 (19%)
		TSP3 repeat_long	496..531	CDD:275366	7/36 (19%)
		TSP_3	497..531	CDD:280556	7/35 (20%)
		TSP type-3 3	532..554		5/28 (18%)
		TSP3 repeat_short	532..554	CDD:275366	5/28 (18%)
		TSP type-3 4	555..590		5/18 (28%)
		TSP3 repeat_long	555..590	CDD:275365	5/18 (28%)
		Cell attachment site. /evidence=ECO:0000255	562..564		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..672
		TSP3 repeat_short	591..613	CDD:275365
		TSP3 repeat_long	614..651	CDD:275365
		TSP_3	615..651	CDD:280556
		TSP type-3 7	652..691
		TSP3 repeat_short	652..691	CDD:275366
		TSP type-3 8	692..727
		TSP3 repeat_long	692..723	CDD:275365
		TSP_3	693..726	CDD:280556
		TSP_C	745..942	CDD:283408
cubn-1	NP_506157.3	EGF_CA	169..205	CDD:238011	8/37 (22%)
		EGF_CA	207..248	CDD:238011	10/41 (24%)
		EGF_CA	306..345	CDD:214542	20/51 (39%)
		EGF_CA	346..387	CDD:214542	19/41 (46%)
		EGF_3	392..429	CDD:372403	13/39 (33%)
		EGF_CA	443..475	CDD:238011	3/31 (10%)
		EGF	480..509	CDD:333761	8/28 (29%)
		CUB	645..762	CDD:238001
		CUB	769..932	CDD:238001
		CUB	1065..1181	CDD:238001
		CUB	1210..1297	CDD:381774
		CUB	1313..1424	CDD:214483
		CUB	1428..1557	CDD:238001
		CUB	1584..1676	CDD:214483
		CUB	1691..>1733	CDD:381774
		CUB	1964..2053	CDD:214483
		CUB	2207..2332	CDD:238001
		CUB	2350..2458	CDD:381774
		CUB	2482..2585	CDD:214483
		CUB	2603..2699	CDD:214483
		CUB	2721..>2766	CDD:381774
		CUB	2996..3120	CDD:238001
		CUB	3127..3253	CDD:238001
		CUB	3264..3382	CDD:214483
		CUB	3387..3503	CDD:238001
		CUB	3515..3640	CDD:238001
		CUB	3672..3764	CDD:381774
		CUB	3786..3899	CDD:238001
		CUB	3918..4033	CDD:381774
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910