DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THBS3 and thbs3

DIOPT Version :9

Sequence 1:	XP_011508228.1	Gene:	THBS3 / 7059	HGNCID:	11787	Length:	1016	Species:	Homo sapiens
Sequence 2:	NP_001011401.1	Gene:	thbs3 / 496875	XenbaseID:	XB-GENE-5761978	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	932	Identity:	752/932 - (80%)
Similarity:	833/932 - (89%)	Gaps:	3/932 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    84 IIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVG 148
            :||||||.|||.|..|.||||:.||...|:|.|||||||||.|||||||||::|||:|||||:||
Frog    30 VIDLLTVSESRHMSGVVEKIRSELLAVNDLYFLSTFRLPPKAGGVLFGLYSKKDNTKWLEASIVG 94

Human   149 KINKVLVRYQREDGKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYVDCKLGDQHAGLPA 213
            |||||||||.|||.|:|||:||.|.|:||..||::||:.|....:.:|.||||||..|...|||.
Frog    95 KINKVLVRYMREDSKLHAVSLQNANLSDGNMHTMILRVSGFRGDTLSLELYVDCKQVDTSLGLPE 159

Human   214 LAPIPPAEVDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDESIHSAVTNALH 278
            :..||..||:..:||:|.||||||||.|||||:|||||::|||||||||||.|||||:.|...::
Frog   160 MMIIPQFEVESGDIRSGHKAYLRMQGSVESMKLILGGSLSRVGALSECPFQEDESIHNTVNGVVN 224

Human   279 SILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRSHCSPNPCFRG 343
            |||||.||||:.|:||||::|.|||:||||||||||||||||||||||||||.||.|:|||||:|
Frog   225 SILGEHTKALIAQMTLFNKVLAELREDIRDQVKEMSLIRNTIMECQVCGFHEHRSRCNPNPCFQG 289

Human   344 VDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPGFHCEACPRGYKGT 408
            |||||.|||||:||||||||.|||||||:||:||:||:|||.||.||||.|||.||.|||||||.
Frog   290 VDCMETYEYPGFRCGPCPPGSQGNGTHCADIDECSHANPCFSGSKCINTSPGFRCEHCPRGYKGN 354

Human   409 QVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGFLGNQSQGCLPAR 473
            .|||||:|||:||||||.||||||||||||||.|||||||||||:||||:.||:|||:.||.|.:
Frog   355 TVSGVGVDYAKASKQVCKDIDECNDGNNGGCDANSICTNTVGSFRCGPCKPGFVGNQTVGCAPKK 419

Human   474 TCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQALPCMDNNKHCKQD 538
            :|.|||.:|||::.||:|||:|.::|.|||||||||..||.|||:|||||:.:||:||||||:||
Frog   420 SCASPAFNPCHLNGHCVFERSGDITCACNVGWAGNGYTCGRDTDLDGYPDEPMPCIDNNKHCRQD 484

Human   539 NCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVP 603
            ||.||||||||||||||:|||||:||||||||||||||||.||||||||||||||||||||||||
Frog   485 NCRLTPNSGQEDADNDGIGDQCDEDADGDGIKNVEDNCRLVPNKDQQNSDTDSFGDACDNCPNVP 549

Human   604 NNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQVQ 668
            ||||:|||.||||||||||:|||||||.||||||||||||||||.||||||||||||.|||||.
Frog   550 NNDQRDTDANGEGDACDNDIDGDGIPNMLDNCPKVPNPLQTDRDLDGVGDACDSCPEASNPTQA- 613

Human   669 GDDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVP 733
              |||||||||:||||:|.|||||||||||||.:||||||||||||.|||||.||||||||||:|
Frog   614 --DADSDLVGDMCDTNQDRDGDGHQDTKDNCPDIPNSSQLDSDNDGKGDECDQDDDNDGIPDYMP 676

Human   734 PGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEG 798
            ||||||||:.|||||||||:|||||||:|||||.|:|||||||||||||||||||||||:|||||
Frog   677 PGPDNCRLMHNPNQKDSDGDGVGDVCEEDFDNDTVIDPLDVCPESAEVTLTDFRAYQTVILDPEG 741

Human   799 DAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGR 863
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||..
Frog   742 DAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFSYQDSSS 806

Human   864 FYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRN 928
            |||||||||||||||||||||||:||||||||.|.:||||.||||||:||||.|||||||.||||
Frog   807 FYVVMWKQTEQTYWQATPFRAVAEPGLQLKAVKSTTGPGEQLRNALWNTGHTQDQVRLLWKDPRN 871

Human   929 VGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQ 993
            |||:|||||||||:|||||||||||||||..|||||||||||:||||||||||||||||||||||
Frog   872 VGWKDKTSYRWQLMHRPQVGYIRVKLYEGVDLVADSGVIIDTNMRGGRLGVFCFSQENIIWSNLQ 936

Human   994 YRCNDTVPEDFEPFRRQLLQGR 1015
            ||||||:||||||:||.|.:|:
Frog   937 YRCNDTIPEDFEPYRRGLQEGK 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THBS3	XP_011508228.1	LamG	85..250	CDD:304605	107/164 (65%)
		coiled coil	284..326	CDD:293925	33/41 (80%)
		TSP-3cc	284..326	CDD:293925	33/41 (80%)
		EGF_CA	373..408	CDD:238011	26/34 (76%)
		EGF_3	435..464	CDD:289699	23/28 (82%)
		TSP3 repeat_1C	515..548	CDD:275367	25/32 (78%)
		TSP3 repeat_short	585..607	CDD:275365	21/21 (100%)
		TSP3 repeat_long	608..643	CDD:275366	30/34 (88%)
		TSP_3	609..643	CDD:280556	30/33 (91%)
		TSP3 repeat_short	644..666	CDD:275366	19/21 (90%)
		TSP_3	671..707	CDD:280556	30/35 (86%)
		TSP_3	749..782	CDD:280556	28/32 (88%)
		TSP_C	801..998	CDD:283408	180/196 (92%)
thbs3	NP_001011401.1	LamG	<58..196	CDD:389952	90/137 (66%)
		coiled coil	230..272	CDD:293925	33/41 (80%)
		TSP-3cc	230..272	CDD:293925	33/41 (80%)
		EGF_CA	319..355	CDD:238011	27/35 (77%)
		EGF_3	381..410	CDD:372403	23/28 (82%)
		TSP3 repeat_short	460..494	CDD:275365	25/33 (76%)
		MSCRAMM_SdrC	<461..662	CDD:380146	177/203 (87%)
		TSP_3	495..530	CDD:367074	31/34 (91%)
		TSP3 repeat_long	495..530	CDD:275366	31/34 (91%)
		TSP3 repeat_short	531..553	CDD:275366	21/21 (100%)
		TSP_3	554..589	CDD:367074	30/34 (88%)
		TSP3 repeat_long	554..589	CDD:275366	30/34 (88%)
		TSP3 repeat_short	590..612	CDD:275366	19/21 (90%)
		TSP3 repeat_long	613..650	CDD:275365	30/39 (77%)
		TSP3 repeat_short	651..690	CDD:275366	33/38 (87%)
		TSP_3	691..725	CDD:367074	29/33 (88%)
		TSP_C	744..941	CDD:368586	180/196 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	392	1.000	Domainoid score	I6205
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5159
Inparanoid	1	1.050	1671	1.000	Inparanoid score	I1082
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0011426
OrthoInspector	1	1.000	-	-		oto147910
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060