DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THBS3 and thbs3a

DIOPT Version :9

Sequence 1:	XP_011508228.1	Gene:	THBS3 / 7059	HGNCID:	11787	Length:	1016	Species:	Homo sapiens
Sequence 2:	NP_775332.1	Gene:	thbs3a / 252849	ZFINID:	ZDB-GENE-020708-3	Length:	962	Species:	Danio rerio

Alignment Length:	945	Identity:	666/945 - (70%)
Similarity:	787/945 - (83%)	Gaps:	12/945 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    75 LWGAVS----VFPIIDLLTVGESRQMVAVAEKIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSR 135
            :|.|.|    ..|:||:|.:.:.:|.||..||:..||.|..|:|::||||||||.||||.|||::
Zfish    18 VWSAQSDKKQDVPVIDVLGLEDVKQTVAAVEKLSLALKTLSDVYVMSTFRLPPKLGGVLLGLYNK 82

Human   136 QDNTRWLEASVVGKINKVLVRYQREDGKVHAVNLQQAGLADGRTHTVLLRLRGPSRPSPALHLYV 200
            |||.::||.:::.|||||||||.|||||:|.||:|...:||||..:::||:.|..|...:|.|||
Zfish    83 QDNKKYLEVAIMSKINKVLVRYVREDGKLHTVNMQSPNVADGRPQSLILRVGGLRREYLSLELYV 147

Human   201 DCKLGDQHAGLPALAPIPPAEVDGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQG 265
            :|:|.|....||.|..: |.:.:.:|||.|.|||.||||.::::|:.|||::|:.|||::|||||
Zfish   148 NCRLADSAQRLPPLVDL-PRDAELVEIRNGHKAYARMQGSMDTLKLALGGTVAQAGALTDCPFQG 211

Human   266 DESIHSAVTNALHSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHE 330
            |.|.::.|...::||||:.||||:.||.:|||||.|||:|||:|||||||:||.|:|||:|||||
Zfish   212 DASSYNIVNGEVNSILGDHTKALIGQLIIFNQILGELREDIREQVKEMSLVRNAILECQMCGFHE 276

Human   331 QRSHCSPNPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHADPCFPGSSCINTMPG 395
            .||.|.|||||:||.|||.:|||||||||||.|:.||||||.||:||:.|.||:...:|:||..|
Zfish   277 PRSRCQPNPCFKGVSCMETFEYPGYRCGPCPDGMTGNGTHCQDIDECSEAQPCYTPGACVNTARG 341

Human   396 FHCEACPRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLG 460
            |.||:||.|..|..:||||::||::.:|.|:|||||.|..| .|.|||:|.||:|||:||.|:.|
Zfish   342 FTCESCPPGMWGPPLSGVGVEYAKSHRQECSDIDECVDLAN-ACTPNSVCINTIGSFRCGQCKTG 405

Human   461 FLGNQSQGCLPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAGNGNVCGTDTDIDGYPDQA 525
            ::|||:.||.|.::|.|.:.:||..:|||:.:|||.|||.|||||||||:.||.|||||||||::
Zfish   406 YVGNQTAGCFPRKSCSSLSFNPCDTNAHCVMQRNGDVSCACNVGWAGNGHTCGKDTDIDGYPDRS 470

Human   526 LPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCRLFPNKDQQNSDTD 590
            ||||||:|||:||||:.|||||||||||||:|||||:||||||||||||||||..||||||||||
Zfish   471 LPCMDNHKHCRQDNCVYTPNSGQEDADNDGIGDQCDEDADGDGIKNVEDNCRLVSNKDQQNSDTD 535

Human   591 SFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPKVPNPLQTDRDEDGVGDAC 655
            ||||||||||.|||.||||||.||||||||:|:|||||.|.||||||||||:|||||.|||||||
Zfish   536 SFGDACDNCPTVPNIDQKDTDSNGEGDACDDDIDGDGIQNVLDNCPKVPNPMQTDRDRDGVGDAC 600

Human   656 DSCPEMSNPTQVQGDDADSDLVGDVCDTNEDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECD 720
            |||||:|||.|.   |.|:||||||||||:|:||||||||:||||.:||||||||||||:||:||
Zfish   601 DSCPEISNPMQT---DVDNDLVGDVCDTNQDTDGDGHQDTRDNCPDIPNSSQLDSDNDGIGDDCD 662

Human   721 GDDDNDGIPD---YVPPGPDNCRLVPNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVT 782
            .|||||||||   ....|||||||:.||||||||.||||||||:|||||:|:|.:||||||||||
Zfish   663 EDDDNDGIPDNHAINGIGPDNCRLISNPNQKDSDSNGVGDVCENDFDNDSVMDLVDVCPESAEVT 727

Human   783 LTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVT 847
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   728 LTDFRAYQTVILDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVT 792

Human   848 DDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHT 912
            |||||||:|.||||..|||||||||||||||:.||||:|:||||||||.|.:||||.|||||||.
Zfish   793 DDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQSIPFRAMAEPGLQLKAVKSRTGPGEFLRNALWHA 857

Human   913 GHTPDQVRLLWTDPRNVGWRDKTSYRWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRL 977
            |.|..:|:|||.|||||||.|||||||||.|||||||||||||||.::||||.|:||||||||||
Zfish   858 GDTDGEVKLLWKDPRNVGWLDKTSYRWQLSHRPQVGYIRVKLYEGSEMVADSDVVIDTSMRGGRL 922

Human   978 GVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLL 1012
            |||||||||||||||:|||||||||||...|:|:|
Zfish   923 GVFCFSQENIIWSNLRYRCNDTVPEDFSSHRKQVL 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THBS3	XP_011508228.1	LamG	85..250	CDD:304605	83/164 (51%)
		coiled coil	284..326	CDD:293925	30/41 (73%)
		TSP-3cc	284..326	CDD:293925	30/41 (73%)
		EGF_CA	373..408	CDD:238011	17/34 (50%)
		EGF_3	435..464	CDD:289699	15/28 (54%)
		TSP3 repeat_1C	515..548	CDD:275367	26/32 (81%)
		TSP3 repeat_short	585..607	CDD:275365	19/21 (90%)
		TSP3 repeat_long	608..643	CDD:275366	29/34 (85%)
		TSP_3	609..643	CDD:280556	28/33 (85%)
		TSP3 repeat_short	644..666	CDD:275366	19/21 (90%)
		TSP_3	671..707	CDD:280556	28/35 (80%)
		TSP_3	749..782	CDD:280556	26/32 (81%)
		TSP_C	801..998	CDD:283408	169/196 (86%)
thbs3a	NP_775332.1	LamG	<58..196	CDD:304605	72/138 (52%)
		coiled coil	230..272	CDD:293925	30/41 (73%)
		TSP-3cc	230..272	CDD:293925	30/41 (73%)
		EGF_CA	319..354	CDD:238011	17/34 (50%)
		EGF_CA	373..408	CDD:238011	21/35 (60%)
		TSP type-3 1	459..493		26/33 (79%)
		TSP type-3 2	494..529		30/34 (88%)
		TSP3 repeat_long	494..529	CDD:275366	30/34 (88%)
		TSP_3	495..529	CDD:280556	29/33 (88%)
		TSP type-3 3	530..552		19/21 (90%)
		TSP3 repeat_short	530..552	CDD:275366	19/21 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..704		124/158 (78%)
		TSP3 repeat_long	553..588	CDD:275366	29/34 (85%)
		TSP_3	554..588	CDD:280556	28/33 (85%)
		TSP3 repeat_short	589..611	CDD:275365	19/21 (90%)
		TSP3 repeat_long	612..649	CDD:275365	28/39 (72%)
		TSP_3	613..649	CDD:280556	28/35 (80%)
		TSP3 repeat_short	650..692	CDD:275366	29/41 (71%)
		TSP type-3 8	693..728		28/34 (82%)
		TSP_3	694..727	CDD:280556	26/32 (81%)
		TSP_C	746..943	CDD:283408	169/196 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339092
Domainoid	1	1.000	224	1.000	Domainoid score	I11101
eggNOG	1	0.900	-	-		E1_2CMRF
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5159
Inparanoid	1	1.050	1461	1.000	Inparanoid score	I1014
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49685
OrthoDB	1	1.010	-	-		D120983at2759
OrthoFinder	1	1.000	-	-		FOG0011426
OrthoInspector	1	1.000	-	-		otm28762
orthoMCL	1	0.900	-	-		OOG6_101187
Panther	1	1.100	-	-	LDO	PTHR10199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.270