DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak4 and Pak

DIOPT Version :9

Sequence 1:	NP_081746.1	Gene:	Pak4 / 70584	MGIID:	1917834	Length:	593	Species:	Mus musculus
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	252/773 - (32%)
Similarity:	355/773 - (45%)	Gaps:	201/773 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 GKKKKRVE----ISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI-------EESARRPKPLID- 55
            |.|....:    ||.|:||||.||.|||....:|||:|..|..|:       :|..:.|:.::|
  Fly    71 GSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDV 135

Mouse    56 -----------PAC-----------------ITSIQPGAPKT--IVRGSK------GAKDGALTL 84
                       |:.                 ::|..|.:..|  .:.||.      |.:.|::||
  Fly   136 LKWFDNTTKQRPSSKYMTNAITTHSGSSLSRVSSSSPSSTPTDSELHGSNSGGNLIGVQLGSMTL 200

Mouse    85 -------------------------------LLDEFEN---MSVTRSNSL--------------- 100
                                           ||.:..|   |.:::|:|.
  Fly   201 GPNANNVAVAGQILGNHYQQQQQHLLQQQQPLLHQNHNQHHMGISQSHSYNFVGHTVSSSTSQHS 265

Mouse   101 -------------RRESPPPPARAHQENGM---------LEERAAPARMAP------------DK 131
                         :::.||||..:..|...         |:....|..:||            ..
  Fly   266 SANEDDMLGPQHPQQQPPPPPVASRPERTKSIYTRPIEDLQPAIIPMPVAPATTPATPLQNHRTP 330

Mouse   132 AGSRARATG---HSEAGSGSGDRRRVGPEKRP---KSSRDGPGGPQEASRDKRPLSGPDVST--- 187
            .|..|.|..   |:.|.:.....:.......|   |::.:..|  .:|:......:.|..||
  Fly   331 GGISAPAASPMMHNNATTTLDKNKNNATPTSPTTTKTTAETEG--TDATSTLLSATNPSCSTTPT 393

Mouse   188 --PQP----GSL------------------TSGTKLAAGRPFNTYPRADTDHPPRGAQGEPHTMA 228
              |.|    |||                  |:....::...|:::|....|.....|....|...
  Fly   394 TDPAPAAPRGSLVETATAHATTAAATVATSTTTNHHSSASSFSSFPSFHDDDGTHHALPTIHCPT 458

Mouse   229 PNG---------PSATGL------AAPQSSSSSRP------PTRAR---GAPSPGVLGPHASEPQ 269
            |..         |.|..|      |:|..:|...|      ||.|:   |.||..|.|...:.||
  Fly   459 PTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESPDLYTPEPTVAQVSAGGPSSQVAGNQIAVPQ 523

Mouse   270 LAPPARALAAPAVPPAPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGST 334
                  |..|||     ..|..|:...:.:::|.|:....|:.:|..|||........|||:|::
  Fly   524 ------AAVAPA-----ATPNTRAANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGAS 577

Mouse   335 GIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVVEMYNSYLVGDELWVVMEF 399
            |.|..|...|:|..||:|:|:|.:|.::||:.||:::||:.:|.|||...:||||.:|||||||:
  Fly   578 GTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEY 642

Mouse   400 LEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFC 464
            |.||:|||:||.|.|:|.||||||..|||||..|||..|||||||||:|||..||.|||:|||||
  Fly   643 LPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFC 707

Mouse   465 AQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMVDGEPPYFNEPPLKAMKMI 529
            ||:|.|..:|.::||||||||||:::|..|||:||:||||:|.||||:|||||.||.||||:.:|
  Fly   708 AQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLI 772

Mouse   530 RDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTKAGPPASIVPLM 587
            ..|..|.:|...|.|.:.:.|||:.|..:..:||:|.:|||||||..|.|.||:.||:
  Fly   773 ATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak4	NP_081746.1	CRIB_PAK_like	10..48	CDD:238526	19/48 (40%)
		Linker	25..322		90/480 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..303		58/313 (19%)
		PKc_like	302..593	CDD:389743	157/286 (55%)
Pak	NP_001138013.2	PBD	83..137	CDD:279166	21/53 (40%)
		STKc_PAK_I	558..818	CDD:270814	146/259 (56%)
		S_TKc	566..817	CDD:214567	142/250 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920