DRSC/TRiP Functional Genomics Resources

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Protein Alignment THBS1 and F14H12.3

DIOPT Version :9

Sequence 1:NP_003237.2 Gene:THBS1 / 7057 HGNCID:11785 Length:1170 Species:Homo sapiens
Sequence 2:NP_508745.1 Gene:F14H12.3 / 180709 WormBaseID:WBGene00017471 Length:257 Species:Caenorhabditis elegans


Alignment Length:242 Identity:87/242 - (35%)
Similarity:106/242 - (43%) Gaps:48/242 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   364 PDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCE-GSSVQTRTCHIQE 427
            |.|  |..|..|..    ||.|:||:|||.:.|..:|.|.|.|.|.|  |: ||:.:::.|.:.:
 Worm    27 PSG--CNVCGDSPQ----WSGWTEWSSCSAAFGTPVQTRTRLCPSGN--CQGGSTTESKPCVLYD 83

Human   428 CDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNG---KPCEGEARETKACKKDAC 489
            ......|   |..|..|||||.|||.|.:||.|:||      ||   ..|.|.|.|::||....|
 Worm    84 PQPTQPQ---WGAWGGWSSCSATCGGGTMTRSRVCN------NGCSTCQCVGAAAESQACNAQPC 139

Human   490 PINGGWGPWSPWDICSVTCG-GGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQ-DCPIDGCL 552
            ..   |..||.|..|||||| ||...|||.|:      .|..|.|...|.:.|.:| .||...|.
 Worm   140 CT---WTAWSSWSACSVTCGSGGSITRSRQCS------CGSGCTGGSVEQEPCPQQAACPCTTCN 195

Human   553 S-----NPC-------FAGVKCTS--YPDGSWKCGACPPGYS--GNG 583
            .     |.|       .....||:  .|.....||...|.|.  |||
 Worm   196 QPPPPCNTCNTQPVVIVTPAPCTTCYQPPACSTCGHAQPFYDPYGNG 242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
THBS1NP_003237.2 TSPN 26..221 CDD:214560
Heparin-binding 47..95
VWC 318..372 CDD:278520 3/7 (43%)
TSP_1 383..428 CDD:395043 18/45 (40%)
TSP1 438..490 CDD:214559 24/54 (44%)
TSP1 495..547 CDD:214559 22/53 (42%)
EGF_3 650..689 CDD:403986
TSP type-3 1 691..726
TSP3 repeat_1C 691..726 CDD:275367
TSP type-3 2 727..762
TSP type-3 3 763..785
TSP3 repeat_short 763..785 CDD:275365
TSP type-3 4 786..821
TSP_3 786..821 CDD:367074
TSP3 repeat_long 787..821 CDD:275366
TSP type-3 5 822..844
TSP3 repeat_short 822..844 CDD:275366
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..934
TSP3 repeat_long 845..882 CDD:275365
TSP_3 846..882 CDD:367074
TSP3 repeat_short 883..918 CDD:275366
TSP type-3 8 919..954
TSP_3 919..952 CDD:367074
Cell attachment site. /evidence=ECO:0000305 926..928
TSP_C 972..1169 CDD:399035
F14H12.3NP_508745.1 TSP_1 <39..86 CDD:301595 19/48 (40%)
TSP1 91..139 CDD:214559 24/53 (45%)
TSP1 142..187 CDD:214559 21/50 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001167
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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