DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THBD and frac

DIOPT Version :9

Sequence 1:	NP_000352.1	Gene:	THBD / 7056	HGNCID:	11784	Length:	575	Species:	Homo sapiens
Sequence 2:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	162/641 - (25%)
Similarity:	217/641 - (33%)	Gaps:	215/641 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    21 AEPQPGGSQCVE--------HDCFAL----YPGPATFLN---ASQICDGLRG----------HLM 60
            :|.||.|..|..        .||..:    ..||....|   ..|.|:...|          ||:
  Fly   388 SESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLL 452

Human    61 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQ-LPPG---CGDPKRLGPLRGFQ------------ 109
            ..:.|.|.|..:.|.|..  :.|.|.....| ||.|   |..||      |::
  Fly   453 EDQRSCALDSCTDLENPQ--LNRTRCAHECQDLPEGSYRCVCPK------GYELSEDQHSCLVQE 509

Human   110 ----------------WVTGDNNTSYS----------RWARLDLN----GAPLCGPLCVAVSAA- 143
                            .:..::|||:|          .::..|::    ...||...|......
  Fly   510 SPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGY 574

Human   144 ------------EATVPSEPIWE------EQQC--------------EVKADGFLCE-------- 168
                        |.|..:|.:.|      ||.|              .:.|||..||
  Fly   575 QCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVN 639

Human   169 -FHFPATCRPLAVEPGAAAAAVSITYGTPFAA----------RGADF-------QALPVGSSAAV 215
             ......||.|   ||        :||...||          ||..|       :..........
  Fly   640 NGGCQQVCRNL---PG--------SYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLC 693

Human   216 APLGLQLMCTAPPGAVQG----------------HWAREAPGAW------DCSVENGGCEHACNA 258
            ..|.....|..|||...|                ..:.|.|.|.      :||:.||.|.|.|..
  Fly   694 ENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHFCQN 758

Human   259 IPGAPRCQCPAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQ 320
            .||..:|.||.|.||..|.|:|  .....|   |..|...|:   :|||.::|.||||:.|..|.
  Fly   759 EPGGFQCACPLGYALSEDMRTC--QDIDECLDSNGQCSQLCL---NQPGGFACACETGFELTPDG 818

Human   321 HRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGE--CVEPVDPC---FRANCEYQCQP 380
            ..|.|:|:|..:...|...|:|..|...|.|...|:|...:  |:: ||.|   ....|.::|
  Fly   819 FGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLD-VDECAGLLSGGCSHEC-- 880

Human   381 LNQT-SYLCVCAEGFAPIPHEPHRCQMFCNQTACPA--DCDPNTQASC------ECPEGYILDDG 436
            :|:. ::.|.|..|:  |.::..|       :..||  .|.|.||.|.      ||..||.|...
  Fly   881 INKAGTFECGCPLGY--ILNDDGR-------SCSPALVGCPPGTQRSADGCAPIECNPGYTLGSD 936

Human   437 FICTDIDEC--ENGGFCSGVCHNLPGTFECICGP------DSALARHIGTDCDSGK 484
            ..|.|||||  :||| ||..|.|..|:|:|.|.|      |....:.| .:||..|
  Fly   937 DKCVDIDECQKQNGG-CSHRCSNTEGSFKCSCPPGYELDSDQKTCQDI-DECDQDK 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THBD	NP_000352.1	CLECT_thrombomodulin_like	30..171	CDD:153070	46/253 (18%)
		FXa_inhibition	245..280	CDD:291342	17/34 (50%)
		FXa_inhibition	289..323	CDD:291342	13/33 (39%)
		EGF_CA	325..>355	CDD:214542	9/29 (31%)
		Tme5_EGF_like	406..439	CDD:286192	12/40 (30%)
		EGF_CA	441..>468	CDD:214542	16/28 (57%)
		Involved in alpha-L/beta-2 and alpha-M/beta-2 integrin binding. /evidence=ECO:0000269\|PubMed:27055590	481..515		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..506		1/1 (100%)
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433	3/18 (17%)
		FXa_inhibition	425..458	CDD:291342	6/32 (19%)
		FXa_inhibition	476..505	CDD:291342	8/34 (24%)
		vWFA	<550..586	CDD:294047	4/35 (11%)
		FXa_inhibition	596..630	CDD:291342	7/33 (21%)
		FXa_inhibition	636..>664	CDD:291342	9/38 (24%)
		EGF_CA	676..715	CDD:284955	6/38 (16%)
		FXa_inhibition	745..780	CDD:291342	17/34 (50%)
		FXa_inhibition	786..821	CDD:291342	14/37 (38%)
		FXa_inhibition	827..862	CDD:291342	9/34 (26%)
		FXa_inhibition	874..904	CDD:291342	8/40 (20%)
		FXa_inhibition	945..980	CDD:291342	14/35 (40%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910