DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment THBD and thbd

DIOPT Version :9

Sequence 1:	NP_000352.1	Gene:	THBD / 7056	HGNCID:	11784	Length:	575	Species:	Homo sapiens
Sequence 2:	XP_017208183.1	Gene:	thbd / 108180329	ZFINID:	ZDB-GENE-110411-281	Length:	515	Species:	Danio rerio

Alignment Length:	547	Identity:	169/547 - (30%)
Similarity:	252/547 - (46%)	Gaps:	108/547 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     9 ALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVIS- 72
            |||.|.||  ..|....|  .||:..||.:....|.|..|.::|:...|||||:|::..|||:|
Zfish     7 ALAFALLG--VHANKYIG--DCVDGKCFVVQTDTANFDAAQKVCEERTGHLMTIRTAKLADVLSR 67

Human    73 LLLNGDGGVGRRRLWIGLQ-LPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPL 136
            |||.|:.|    ..||||: :...|.|     .|:|::|:|||:.:.:|.|.|     ...|.|.
Zfish    68 LLLKGESG----NFWIGLRYVGNECSD-----RLKGYKWITGDDTSHFSNWKR-----ESDCAPS 118

Human   137 CVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARG 201
            ||:||      .::..|.|:.|..:.||::||::....|.||:.:.       .:.|.|.|....
Zfish   119 CVSVS------QNDHKWTERPCSDRIDGYVCEYNNLNHCPPLSTDE-------KVHYSTAFGFTS 170

Human   202 AD-FQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRC 265
            .: .:.:|..::|....|..:.:|      ....|. .||  |:|.|.:|||::.|.....:..|
Zfish   171 NELLREIPELTNATRLDLRTKHIC------FDSEWL-HAP--WNCEVFDGGCDYTCVRNGQSYAC 226

Human   266 QCPAGAALQADGRSCTASATQS-CNDL-CEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDD 328
            .|..|..|..:|.||:...... |... |||.|..:   .|:::|.|..|:.|:||...|::
Zfish   227 ICQPGFKLDTNGISCSQQQDDDPCAHAGCEHECARD---SGAFACTCRPGFTLSADGKSCKE--- 285

Human   329 CILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEG 393
                                 :|.|.|...:|.||: ||.|....||:.|.. .:.||.|||.:|
Zfish   286 ---------------------NCKPGYINENGGCVD-VDECATGPCEHDCAN-TEGSYQCVCFDG 327

Human   394 FAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILD-DGFICTDIDECENGGFCSGVCHN 457
            :.|...:.|:|:|.|....|.|:||||....|:||:|::.| |...|.|:|||.:...|...|.|
Zfish   328 YKPAAKDMHKCKMHCPDMRCKAECDPNNDYQCDCPDGFLFDEDDRYCVDVDECISTNDCDQNCTN 392

Human   458 LPGTFECICGPDSALARHIGTDCDSG---KVDGGDSGSGEP---------PPSPTPGSTLTPPAV 510
            .||:|||.|.....|       .|:|   .::|  |||..|         ||:..|.|
Zfish   393 TPGSFECFCHEGYVL-------LDNGVCEDLEG--SGSSTPFDLFIPTSRPPTDRPLS------- 441

Human   511 GLVHSGLLIGISIASLCLVVALLALLC 537
              :.:|.|:|:.:   |:||.:|.|:|
Zfish   442 --ISAGSLLGVMV---CVVVCVLLLVC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
THBD	NP_000352.1	CLECT_thrombomodulin_like	30..171	CDD:153070	51/142 (36%)
		FXa_inhibition	245..280	CDD:291342	11/34 (32%)
		FXa_inhibition	289..323	CDD:291342	11/34 (32%)
		EGF_CA	325..>355	CDD:214542	2/29 (7%)
		Tme5_EGF_like	406..439	CDD:286192	14/33 (42%)
		EGF_CA	441..>468	CDD:214542	13/26 (50%)
		Involved in alpha-L/beta-2 and alpha-M/beta-2 integrin binding. /evidence=ECO:0000269\|PubMed:27055590	481..515		11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..506		9/30 (30%)
thbd	XP_017208183.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28V1U
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I10534
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG38551
OrthoDB	1	1.010	-	-		D331777at7742
OrthoFinder	1	1.000	-	-		FOG0009684
OrthoInspector	1	1.000	-	-		oto50215
orthoMCL	1	0.900	-	-		OOG6_116313
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	12	12.240