DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TH and ple

DIOPT Version :9

Sequence 1:	NP_954986.2	Gene:	TH / 7054	HGNCID:	11782	Length:	528	Species:	Homo sapiens
Sequence 2:	NP_001286955.1	Gene:	ple / 38746	FlyBaseID:	FBgn0005626	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	239/497 - (48%)
Similarity:	324/497 - (65%)	Gaps:	51/497 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    52 PAASYTPTPRSPRFIGRRQSLIEDARKEREA---------------AVAAAAAAVPSEPGDPLEA 101
            |...|.|......|....|...|...:|.|.               .:.|.||:..|:....:::
  Fly    94 PLEEYVPVEEDVEFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQS 158

Human   102 VAF--EEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVR 164
            .|.  ..|||              .|:|.|.:|..|||...:.|:|:|   :.|..|...:..::
  Fly   159 AALVVRLKEG--------------ISSLGRILKAIETFHGTVQHVESR---QSRVEGVDHDVLIK 206

Human   165 LEVRRGDLAALLSGVRQ------VSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHP 223
            |::.||:|..|:..:||      ::....:....|.||||:..||||.|:||:||::||||::||
  Fly   207 LDMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHP 271

Human   224 GFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFAL 288
            ||:|:|||||||.||||||.|::|||||.::|:..|:.||:.|:.|::.|...|||.|:..||..
  Fly   272 GFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQK 336

Human   289 LERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMH 353
            |:....:.|..:|||:::|.||::.|||.|||.||||:|||||||||||:||.|||:||.:||.|
  Fly   337 LQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYH 401

Human   354 SPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKA 418
            :||||..||||||:|:|||.:||||||:||||||||||||||||||:|||||||||||::|::||
  Fly   402 TPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKA 466

Human   419 YGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQ 483
            ||||||||||||||.:|::.|.|||:|.:.||||||||.||.:|:|:|||.|||||.|.:.|.:.
  Fly   467 YGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMS 531

Human   484 RPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALS 525
            |||.|:|:|:|..::||||           .|:|:||.|.::
  Fly   532 RPFEVRFNPHTERVEVLDS-----------VDKLETLVHQMN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TH	NP_954986.2	TOH_N	2..26	CDD:289326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..65		3/12 (25%)
		TOH_N	37..61	CDD:289326	3/8 (38%)
		Tyr_3_monoox	69..525	CDD:130336	235/478 (49%)
		ACT_TH	69..190	CDD:153202	31/143 (22%)
		Biopterin_H	195..525	CDD:278766	203/329 (62%)
ple	NP_001286955.1	Tyr_3_monoox	130..576	CDD:130336	231/461 (50%)
		ACT	130..234	CDD:298841	27/120 (23%)
		Biopterin_H	243..573	CDD:278766	203/331 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147586
Domainoid	1	1.000	435	1.000	Domainoid score	I576
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H307
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1560
Isobase	1	0.950	-	0	Normalized mean entropy	S3178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361696at33208
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto88529
orthoMCL	1	0.900	-	-		OOG6_108343
Panther	1	1.100	-	-	O	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4798
SonicParanoid	1	1.000	-	-		X3954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740