Protein Alignment TGFBR2 and Tgfbr2

DIOPT Version :10

• Sequence 1: NP_001394055.1
• Gene: TGFBR2 / 7048
• HGNCID: 11773
• Length: 628
• Species: Homo sapiens
• Sequence 2: XP_008764912.1
• Gene: Tgfbr2 / 81810
• RGDID: 69651
• Length: 592
• Species: Rattus norvegicus
• Alignment Length: 628
• Identity: 534/628 - (85%)
• Similarity: 563/628 - (89%)
• Gaps: 36/628 - (5%)

Human     1 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTD 65
            ||||||||||||||||||||||||||||.||||.||.|:|..|..|||||.|||:|.|:|::..|
  Rat     1 MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSDVGMETQRDISIHLSCNRTVHPLKHFNSDLMAGD 65

Human    66 NNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPK 130
            |:||||.|||||||||..||||||||||||||:|||||||||||||||||||:||||||||||||
  Rat    66 NSGAVKLPQLCKFCDVTLSTCDNQKSCMSNCSVTSICEKPQEVCVAVWRKNDKNITLETVCHDPK 130

Human   131 LPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEGRCKIRHIGSNNRLQRSTC 195
            ..||.|.||||.||.|:|||||:.|||||||||:::||||.|||:|
  Rat   131 FTYHGFTLEDATSPTCVMKEKKRAGETFFMCSCNTEECNDYIIFNE------------------- 176

Human   196 QNTGWESAHVMKTPGFREYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSS 260
                             ||.||:|||||||.||||:|||||||:||:||.|||||||:||||||.
  Rat   177 -----------------EYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIAIFYCYRVHRQQKLSP 224

Human   261 TWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLK 325
            :||:.|.||||:||::|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   225 SWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLK 289

Human   326 QNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHA 390
            ||||||||||||||||||||:|||||||||||||||||||||||||||||||:||||||||||||
  Rat   290 QNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTEMGKQYWLITAFHA 354

Human   391 KGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   355 KGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC 419

Human   456 LCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTS 520
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
  Rat   420 LCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTS 484

Human   521 RCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHD 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
  Rat   485 RCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHD 549

Human   586 PEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK 628
            |||||||||||||||||||.|||||||||:|||||||||||||
  Rat   550 PEARLTAQCVAERFSELEHPDRLSGRSCSQEKIPEDGSLNTTK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR2	NP_001394055.1	ecTbetaR2	74..177	CDD:462632	84/102 (82%)
		STKc_TGFbR2_like	309..603	CDD:270957	289/293 (99%)
Tgfbr2	XP_008764912.1	ecTbetaR2	74..177	CDD:462632	85/138 (62%)
		STKc_TGFbR2_like	273..567	CDD:270957	289/293 (99%)