DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TGFBR2 and tgfbr2b

DIOPT Version :9

Sequence 1:	NP_001020018.1	Gene:	TGFBR2 / 7048	HGNCID:	11773	Length:	592	Species:	Homo sapiens
Sequence 2:	NP_878275.2	Gene:	tgfbr2b / 30739	ZFINID:	ZDB-GENE-980526-375	Length:	556	Species:	Danio rerio

Alignment Length:	528	Identity:	367/528 - (69%)
Similarity:	435/528 - (82%)	Gaps:	17/528 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    71 KFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHD 135
            :.|||||||||..|.|:.:.:|.||||||||||.|.|:|||:||::|:|.|:||:||:|.:|.:.
Zfish    36 RIPQLCKFCDVLESNCNGKDTCESNCSITSICESPDEICVAIWRQSDDNNTIETLCHNPTVPLYG 100

Human   136 FILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPP 200
            .::|:..:.||.||::......|.:|||:..||||.::|  :..|:|..:|:::     :||||.
Zfish   101 IMVENNNNTKCEMKKRISNSGPFHICSCNEVECNDMLLF--KLPTNNQVVLVIL-----VSLLPL 158

Human   201 LGVAISVIIIFYCYRVNRQQKLSSTWETGKTRK------LMEFSEHCAIILEDDRSDISSTCANN 259
            |.:|:.||..||.||:.|::||.. |||.|..|      .::.|:.|||:::|||||.|||.|||
Zfish   159 LVLAVLVIASFYWYRLYRRRKLDE-WETKKPSKHKGPKGALDCSDACAIMMDDDRSDSSSTHANN 222

Human   260 INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL 324
            ||||.:.||||||..||||||||||||||:|:.|||||||||||||||||||||.|||||.||:|
Zfish   223 INHNMDPLPIELDLQVGKGRFAEVYKAKLRQSPSEQFETVAVKIFPYEEYASWKNEKDIFQDIDL 287

Human   325 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD 389
            ||||||.||||||||.|  ||||||||||.:|||||||.||::||||||.||||||.|:||||||
Zfish   288 KHENILHFLTAEERKVE--KQYWLITAFHPRGNLQEYLMRHLLSWEDLRLLGSSLASGVAHLHSD 350

Human   390 HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEV 454
            ||||||||:|||||||||||||||||||||||||||.||||.:||||:|||||||||||||||||
Zfish   351 HTPCGRPKVPIVHRDLKSSNILVKNDLTCCLCDFGLGLRLDNSLSVDELANSGQVGTARYMAPEV 415

Human   455 LESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRD 519
            ||||:||||:|||||||||||||||||:||||||:||||||||||||||||||||||||||||||
Zfish   416 LESRINLENIESFKQTDVYSMALVLWEITSRCNAIGEVKDYEPPFGSKVREHPCVESMKDNVLRD 480

Human   520 RGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL-EHLDRLSGRSCSEEKIP 583
            ||||||||.|:.|||:..||.|:.||||||||||||||||||||:|: :.||:||..|.||||||
Zfish   481 RGRPEIPSSWMKHQGVAAVCATINECWDHDPEARLTAQCVAERFNEMDDDLDKLSTCSSSEEKIP 545

Human   584 EDGSLNTT 591
            ||.:::.:
Zfish   546 EDCAVSVS 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR2	NP_001020018.1	ecTbetaR2	74..177	CDD:401023	51/102 (50%)
TGFBR2	NP_001020018.1	STKc_TGFbR2_like	273..567	CDD:270957	254/294 (86%)
tgfbr2b	NP_878275.2	ecTbetaR2	39..139	CDD:286061	50/99 (51%)
		STYKc	232..520	CDD:214568	251/289 (87%)
		STKc_TGFbR2_like	237..528	CDD:270957	254/292 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337091
Domainoid	1	1.000	534	1.000	Domainoid score	I2321
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2435
Inparanoid	1	1.050	749	1.000	Inparanoid score	I3860
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40077
OrthoDB	1	1.010	-	-		D159657at7742
OrthoFinder	1	1.000	-	-		FOG0008994
OrthoInspector	1	1.000	-	-		oto42765
orthoMCL	1	0.900	-	-		OOG6_110623
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8851
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300