DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TGFBR1 and tgfbr1b

DIOPT Version :9

Sequence 1:	NP_001293139.1	Gene:	TGFBR1 / 7046	HGNCID:	11772	Length:	507	Species:	Homo sapiens
Sequence 2:	NP_001108531.1	Gene:	tgfbr1b / 792928	ZFINID:	ZDB-GENE-091027-1	Length:	505	Species:	Danio rerio

Alignment Length:	480	Identity:	401/480 - (83%)
Similarity:	424/480 - (88%)	Gaps:	14/480 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    34 LQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTT 98
            |||:||.|  .|.||.|||||:||:|.........|.||.:.:|:|.|||||||||:|..|....
Zfish    34 LQCYCHRC--PNHTCTTDGLCYVSITRAGSLTTQQSWCIGKGELVPPDRPFVCAPSTKDDSGIYP 96

Human    99 YCCNQDHCNK------IELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTV 157
            .||:.|.|||      ..:||..|      |.||||..||:||||||.:|..::.:.||||:|:|
Zfish    97 LCCDTDWCNKDPDIKAFPVPTQKP------PALGPVAFAALIAGPVCVLCFLMVTVFYICHSRSV 155

Human   158 IHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGE 222
            ||||||:|||||||.|||:.||||||||||||||||||||||||||||||||:||||||||||||
Zfish   156 IHHRVPSEEDPSLDHPFITVGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGE 220

Human   223 VWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYH 287
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   221 VWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYH 285

Human   288 EHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC 352
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Zfish   286 EHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC 350

Human   353 IADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 417
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
Zfish   351 IADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAS 415

Human   418 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYAN 482
            |||||||||||||||:|||.|||||||||:|||||||||||||||||||||||||||||||||||
Zfish   416 RCSIGGIHEDYQLPYHDLVQSDPSVEEMRRVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYAN 480

Human   483 GAARLTALRIKKTLSQLSQQEGIKM 507
            |||||||||||||||||||||||||
Zfish   481 GAARLTALRIKKTLSQLSQQEGIKM 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	39/84 (46%)
		TGF_beta_GS	180..207	CDD:285687	26/26 (100%)
		Pkinase_Tyr	209..496	CDD:285015	279/286 (98%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	280/286 (98%)
tgfbr1b	NP_001108531.1	Activin_recp	34..107	CDD:279413	38/74 (51%)
		TGF_beta_GS	178..205	CDD:285687	26/26 (100%)
		TyrKc	207..494	CDD:197581	279/286 (98%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	280/286 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194334426
Domainoid	1	1.000	572	1.000	Domainoid score	I1948
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3177
Inparanoid	1	1.050	819	1.000	Inparanoid score	I3354
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51262
OrthoDB	1	1.010	-	-		D168605at7742
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm28227
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5155
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300