Protein Alignment TGFBR1 and tgfbr1

DIOPT Version :9

• Sequence 1: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_001015961.1
• Gene: tgfbr1 / 548715
• XenbaseID: XB-GENE-478587
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 499
• Identity: 424/499 - (84%)
• Similarity: 446/499 - (89%)
• Gaps: 11/499 - (2%)

Human    10 PRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAE 74
            |||::|:|.|.|..|.||:       |.|..|.  |.||:|||||.|:|.....||.|||:|||:
 Frog    11 PRLIVLLLIALARWAEALI-------CHCEQCA--NRTCMTDGLCLVNVLIQDGKVTHNSLCIAD 66

Human    75 IDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCN-KIELPTTGPFSVKSSPGLGPVELAAVIAGPV 138
            .:.:||||||:|..:|..|......||..|.|| |:..|:|.| |.:....||||||||||||||
 Frog    67 SERVPRDRPFMCFSTSTNGIYHNVECCQTDFCNKKLPAPSTSP-SPRPPTNLGPVELAAVIAGPV 130

Human   139 CFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQR 203
            |.|||.|||::|||||||||||||||:||||||||||||||||||||||||||||||||||||||
 Frog   131 CLVCILLMLVLYICHNRTVIHHRVPNDEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQR 195

Human   204 TIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 268
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 TIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 260

Human   269 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAI 333
            ||||||||||||||||||||||||||||||||||||||:||:|||||||||||||||||||||||
 Frog   261 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMLKLSLSTASGLAHLHMEIVGTQGKPAI 325

Human   334 AHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFE 398
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   326 AHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFE 390

Human   399 SFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ 463
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   391 SFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMKKVVCEQKLRPNIPNRWQ 455

Human   464 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM 507
            |||||||||||||||||||||||||||||||||||||||||:||
 Frog   456 SCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGLKM 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	37/79 (47%)
		TGF_beta_GS	180..207	CDD:285687	26/26 (100%)
		Pkinase_Tyr	209..496	CDD:285015	283/286 (99%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	283/286 (99%)
tgfbr1	NP_001015961.1	Activin_recp	28..102	CDD:366445	36/82 (44%)
		TGF_beta_GS	172..199	CDD:369918	26/26 (100%)
		STKc_TGFbR1_ACVR1b_ACVR1c	205..492	CDD:271045	283/286 (99%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	580	1.000	Domainoid score	I2635
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3177
Inparanoid	1	1.050	847	1.000	Inparanoid score	I4074
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133913at32523
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		oto157166
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160