DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TGFBR1 and babo

DIOPT Version :9

Sequence 1:	NP_001293139.1	Gene:	TGFBR1 / 7046	HGNCID:	11772	Length:	507	Species:	Homo sapiens
Sequence 2:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	289/538 - (53%)
Similarity:	359/538 - (66%)	Gaps:	54/538 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    21 AAAAAALLP------GATA----------------------LQCFCHLCTKDNFTCVTDGLCFVS 57
            |:|.:.|||      ||.|                      ::|.|..|.:.|..|.|||.||.|
  Fly    86 ASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQPSAKKPENKIKCHCDTCKESNNICETDGFCFTS 150

Human    58 VTETTD-KVIHNSMCIAEIDLIPRDRPFVC------APSSK-TGSVTTTYCC-NQDHCNKIELPT 113
            |.:.:| .:|.:..|:.:..:.|..|...|      .|::: .|......|| ::|.||:...|.
  Fly   151 VEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPK 215

Human   114 T-----------GPFSVKS--SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR-TVIHHRVPN 164
            |           ...||:.  ...|...|..|:|.|...|:|.:.....|.|..| .:...|...
  Fly   216 TKDQRSDRVEEGRQISVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFA 280

Human   165 EEDPSLDRPFISEGTTLKDLIYDMTTSGSGS-GLPLLVQRTIARTIVLQESIGKGRFGEVWRGKW 228
            :||.:.| |.::..||:.|:| :|||||||| ||||||||:|||.:.|...||||||||||||:|
  Fly   281 KEDSAYD-PILNGNTTIHDII-EMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRW 343

Human   229 RGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLF 293
            |||.|||||||||||.|||||||||||||||||||||||||||||||||||||||:||||:||||
  Fly   344 RGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLF 408

Human   294 DYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGL 358
            |||..:.|....|:.::||.|:|||||||:||||:||||||||||||||||||.|.:|.|.||||
  Fly   409 DYLTTHPVDTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGL 473

Human   359 AVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGG 423
            ||||....|::||...|||||||||||||||:|:|.:||:|:||||:||.||:.|||||||::|.
  Fly   474 AVRHVEKNDSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGM 538

Human   424 IHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLT 488
            |:::|||||||:|..|||:|||:||||.:|.||||||||.:.:.|..|||:|:||||.|..||||
  Fly   539 IYDEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLT 603

Human   489 ALRIKKTLSQLSQQEGIK 506
            ||||||||:.:|.::.:|
  Fly   604 ALRIKKTLASISVEDKVK 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	26/87 (30%)
		TGF_beta_GS	180..207	CDD:285687	20/27 (74%)
		Pkinase_Tyr	209..496	CDD:285015	210/286 (73%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	211/286 (74%)
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	25/86 (29%)
		GS	294..324	CDD:197743	23/30 (77%)
		Pkinase_Tyr	324..611	CDD:285015	210/286 (73%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	211/286 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I523
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3177
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1191
Isobase	1	0.950	-	0	Normalized mean entropy	S2949
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm40988
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5155
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810