DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TGFBR1 and sax

DIOPT Version :9

Sequence 1:	NP_001293139.1	Gene:	TGFBR1 / 7046	HGNCID:	11772	Length:	507	Species:	Homo sapiens
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	231/505 - (45%)
Similarity:	309/505 - (61%)	Gaps:	43/505 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    38 CHLC---TKDNF----TCVTDGLCFVSVTETTDKVIHNSM-CIAEIDLIPRDRPFVCAPSS---- 90
            |:.|   .:|.:    ||.....|:.|.|...|..:..|. |...    |...|.:|:.:|
  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTS----PDQLPMICSQNSLKIN 139

Human    91 -----KTGSVTTTYCCNQDHCNKIELPTTGPF-----SVKSSPGLGPVELAAVIAGPVCFVCISL 145
                 .||......||..|:||:.:.|...||     :|.::......::...:.||  |:.|:|
  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGP--FLVIAL 202

Human   146 MLMVYI-----CHNRTVIHHRVPNEEDP-------SLDRPFISEGTTLKDLIYDMTTSGSGSGLP 198
            :..|.|     .|.:.:...|  .::||       .|.|...:..:||::.:....|||||||||
  Fly   203 LGAVTIFFIRRSHRKRLAASR--TKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLP 265

Human   199 LLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENI 263
            ||||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||:|.||.||.|||.|::||||||
  Fly   266 LLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENI 330

Human   264 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 328
            ||||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.|
  Fly   331 LGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQ 395

Human   329 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 393
            ||||:||||||||||||..||:|.|||.||||.|...|..:|:..|.:|||||||||||||:||:
  Fly   396 GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESID 460

Human   394 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNI 458
            ::.||:.:|.||||.|||.||:.||....||.|:|::|:||:||.|||.|:||||||....||:|
  Fly   461 LECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSI 525

Human   459 PNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL-SQQEGIKM 507
            ||||.|...:..|:|:|:|||:.|...||.|||||||:.:| |..|.|::
  Fly   526 PNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	23/92 (25%)
		TGF_beta_GS	180..207	CDD:285687	17/26 (65%)
		Pkinase_Tyr	209..496	CDD:285015	169/286 (59%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	170/287 (59%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/92 (25%)
		TM_EGFR-like	182..218	CDD:213052	8/37 (22%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	173/296 (58%)
		TyrKc	276..553	CDD:197581	161/276 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820