DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TGFBR1 and daf-1

DIOPT Version :9

Sequence 1:	NP_001293139.1	Gene:	TGFBR1 / 7046	HGNCID:	11772	Length:	507	Species:	Homo sapiens
Sequence 2:	NP_001023159.1	Gene:	daf-1 / 176829	WormBaseID:	WBGene00000897	Length:	669	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	172/520 - (33%)
Similarity:	260/520 - (50%)	Gaps:	82/520 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    47 TCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPF------VCAPSSKTGSVTTTYCCNQ-D 104
            ||.|||.|:.|...:.:  |.:..|:.| ..:..:..|      ||..::|....|...||:: :
Worm    89 TCYTDGSCYQSARPSPE--ISHFGCMDE-KSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGN 150

Human   105 HCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMV-----------YICHNRTVI 158
            .|....:....|...:||..|    :..::|.....|.:.:.:.:           ||...
Worm   151 FCANETIIHLAPGPQQSSTWL----ILTILALLTFIVLLGIAIFLTRKSWEAKFDWYIRFK---- 207

Human   159 HHRVPNEEDPSLD---------------------RPFISEGTT-----------------LKDLI 185
                |...||..:                     .|...:|:|                 :||::
Worm   208 ----PKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDML 268

Human   186 YDM--TTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFR 248
             |:  .|||||.|...|.:.||...|.|...:|.||||.|.||.:|||.||||:|::.:|.::.:
Worm   269 -DVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHK 332

Human   249 EAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALST 313
            |.||::|.||||.|:|.:|.:|..|.|..|:||||::||..|||.|:|...||.:|....|..||
Worm   333 ETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRST 397

Human   314 ASGLAHLHMEIVGTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR--HDSATDTIDIAPN 374
            |||||.||.:|.|::  .|||:||||:|||||:||.:.||.|.||||::.  .|:|:|.| ...|
Worm   398 ASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDII-ANEN 461

Human   375 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI---HEDYQLPYYDLV 436
            ::.||.||:|||:|:.::....|||::.||:|:..||.||...||..|.:   .....:||.:..
Worm   462 YKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWT 526

Human   437 PSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQ 501
            ..||...:|..|||.::|||.....|:....::.:.:|::.||..|.:||.|:...:|.:.:..|
Worm   527 DRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQ 591

Human 502 501
Worm 592 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	18/73 (25%)
		TGF_beta_GS	180..207	CDD:285687	13/45 (29%)
		Pkinase_Tyr	209..496	CDD:285015	127/293 (43%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	125/293 (43%)
daf-1	NP_001023159.1	GS	265..293	CDD:197743	12/28 (43%)
		Pkinase_Tyr	293..576	CDD:285015	123/283 (43%)
		STKc_TGFbR_I	297..589	CDD:270958	125/292 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I1477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I2302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm16226
orthoMCL	1	0.900	-	-		OOG6_103647
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5155
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.990