Protein Alignment TGFBR1 and daf-1

DIOPT Version :10

• Sequence 1: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_001023159.1
• Gene: daf-1 / 176829
• WormBaseID: WBGene00000897
• Length: 669
• Species: Caenorhabditis elegans
• Alignment Length: 520
• Identity: 172/520 - (33%)
• Similarity: 260/520 - (50%)
• Gaps: 82/520 - (15%)

Human    47 TCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPF------VCAPSSKTGSVTTTYCCNQ-D 104
            ||.|||.|:.|...:.:  |.:..|:.| ..:..:..|      ||..::|....|...||:: :
 Worm    89 TCYTDGSCYQSARPSPE--ISHFGCMDE-KSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGN 150

Human   105 HCNKIELPTTGPFSVKSSPGLGPVELAAVIAGPVCFVCISLMLMV-----------YICHNRTVI 158
            .|....:....|...:||..|    :..::|.....|.:.:.:.:           ||...
 Worm   151 FCANETIIHLAPGPQQSSTWL----ILTILALLTFIVLLGIAIFLTRKSWEAKFDWYIRFK---- 207

Human   159 HHRVPNEEDPSLD---------------------RPFISEGTT-----------------LKDLI 185
                |...||..:                     .|...:|:|                 :||::
 Worm   208 ----PKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDML 268

Human   186 YDM--TTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFR 248
             |:  .|||||.|...|.:.||...|.|...:|.||||.|.||.:|||.||||:|::.:|.::.:
 Worm   269 -DVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHK 332

Human   249 EAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALST 313
            |.||::|.||||.|:|.:|.:|..|.|..|:||||::||..|||.|:|...||.:|....|..||
 Worm   333 ETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRST 397

Human   314 ASGLAHLHMEIVGTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR--HDSATDTIDIAPN 374
            |||||.||.:|.|::  .|||:||||:|||||:||.:.||.|.||||::.  .|:|:|.| ...|
 Worm   398 ASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDII-ANEN 461

Human   375 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI---HEDYQLPYYDLV 436
            ::.||.||:|||:|:.::....|||::.||:|:..||.||...||..|.:   .....:||.:..
 Worm   462 YKCGTVRYLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWT 526

Human   437 PSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQ 501
            ..||...:|..|||.::|||.....|:....::.:.:|::.||..|.:||.|:...:|.:.:..|
 Worm   527 DRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRMDERQQ 591

Human   502  501
             Worm   592  591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFBR1	NP_001293139.1	TFP_LU_ECD_ALK5	35..108	CDD:467067	18/67 (27%)
		TGF_beta_GS	180..207	CDD:462503	13/45 (29%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	125/293 (43%)
daf-1	NP_001023159.1	TFP	55..152	CDD:480272	17/65 (26%)
		STKc_TGFbR_I	297..589	CDD:270958	125/292 (43%)