Protein Alignment TGFB3 and scw

DIOPT Version :9

• Sequence 1: NP_001316868.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 461
• Identity: 108/461 - (23%)
• Similarity: 177/461 - (38%)
• Gaps: 125/461 - (27%)

Human    14 LLN-FATVSL----SLSTCTTLDFGHIK----KKRVEAIRGQILSKLRLTSPP----EPTVMTHV 65
            :|| |...||    |.:|..|.: .||:    :||..:.:.:::..|.|...|    ||.
  Fly     1 MLNVFFLTSLFYAASATTYVTTN-NHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPN----- 59

Human    66 PYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHK----FDMIQGLAEHNELAVC--- 123
                  |:||..:.|.|::.|     ..|:.|.:....:.||    .|::....:..|:|.|
  Fly    60 ------LHNSASKFLLEVYNE-----ISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSI 113

Human   124 --------PKGITSKV---FRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQIL--R 175
                    |:.:.:::   ..||.:.|..: .:|.:|..|:.:.|:...:|....:.:::.|  |
  Fly   114 LTFSSRLKPEQLDNELDMHITFNTNDVPVD-LSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNR 177

Human   176 PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWL----LRRESNLGLEISIHCPCHTF---- 232
            .|   ...|.:|..| .|.....||.|::|||:|.||    |:|.:.|.:.|. .....||
  Fly   178 QD---FSYRILGSVN-TTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIG-DSQLSTFAAGL 237

Human   233 ----------QP------NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILM 281
                      :|      ||.  |.:.::.:::||          .||.:.:.......|.
  Fly   238 VTPQASRTSLEPFIVGYFNGP--ELLVKIQKLRFK----------RDLEKRRAGGGSPPPP---- 286

Human   282 MIPPHRLD--NPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFC 344
              ||..:|  .|.|..:|      .|:.              :||::.....||..||.:.|.||
  Fly   287 --PPPPVDLYRPPQSCER------LNFT--------------VDFKELHMHNWVIAPKKFEAYFC 329

Human   345 SGPCPY---LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGR-TPKVEQLSNMV 405
            .|.|.:   .:...|.|:.|..|.:...|.. ..|||||..|..:|||.|:.. ...:.:....|
  Fly   330 GGGCNFPLGTKMNATNHAIVQTLMHLKQPHL-PKPCCVPTVLGAITILRYLNEDIIDLTKYQKAV 393

Human   406 VKSCKC 411
            .|.|.|
  Fly   394 AKECGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB3	NP_001316868.1	TGFb_propeptide	24..230	CDD:395559	54/237 (23%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	30/104 (29%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	51/236 (22%)
		TGFB	300..400	CDD:214556	32/121 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810