Protein Alignment TGFB3 and dpp

DIOPT Version :10

• Sequence 1: NP_003230.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 440
• Identity: 99/440 - (22%)
• Similarity: 152/440 - (34%)
• Gaps: 139/440 - (31%)

Human    47 ILSKLRLTSPPEPTVMTHVPYQVLALYNSTR----------------ELLEEMHGEREEGCT--- 92
            |..||:    |:|:.:..:...:|:|:|..|                :|..|:.|...:...
  Fly   212 IKDKLK----PDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPK 272

Human    93 ------QENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFR--FNVSSVEKNRTNLFRA 149
                  ..||...:    .||...|.....|:..           ||  |:|.|:..:. .|..|
  Fly   273 PGLLTKSANTVRSF----THKDSKIDDRFPHHHR-----------FRLHFDVKSIPADE-KLKAA 321

Human   150 EFRVLR--------VPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTR----GTAEWLSF 202
            |.::.|        ....|:.|...::.::.|.|..  :..||......|.|:    .:.:.:|.
  Fly   322 ELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVG--VRGQREPSYLLLDTKTVRLNSTDTVSL 384

Human   203 DVTDTVREWLLRRESNLGLEISIH-------CPCH-----------------------TFQPNGD 237
            ||...|..||...:.|.||.:.:.       .|.|                       |:..:|.
  Fly   385 DVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQHKQPLLFTYTDDGR 449

Human   238 ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302
                 |:...|:    |.....|.|..||.|:|                    |.:..:||
  Fly   450 -----HKARSIR----DVSGGEGGGKGGRNKRQ--------------------PRRPTRRK---- 481

Human   303 DTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRSAD----TTHSTVL 362
                   |.::.|....||:|| .|:|| .|:..|.||.|.:|.|.||: ..||    |.|:.|.
  Fly   482 -------NHDDTCRRHSLYVDF-SDVGWDDWIVAPLGYDAYYCHGKCPF-PLADHFNSTNHAVVQ 537

Human   363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGR-TPKVEQLSNMVVKSCKC 411
            .|.|.:||......||||..|:.:.:||...: |..::....|.|..|.|
  Fly   538 TLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGC 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB3	NP_003230.1	TGFb_propeptide	24..231	CDD:459906	46/252 (18%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	38/106 (36%)
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	41/236 (17%)
		TGF_beta_DPP	480..588	CDD:381662	41/121 (34%)