Protein Alignment TGFB2 and myo

DIOPT Version :10

• Sequence 1: NP_001129071.1
• Gene: TGFB2 / 7042
• HGNCID: 11768
• Length: 442
• Species: Homo sapiens
• Sequence 2: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 100/487 - (20%)
• Similarity: 189/487 - (38%)
• Gaps: 129/487 - (26%)

Human    18 ALSLSTCSTLDMDQFMRKR---------IEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNS 73
            ::||...:.::::..::::         ||:|:..||.:|.|...| :..:|..||..:|.  |.
  Fly   179 SVSLYRNTLINIESMLQRQLREKAKVDSIESIKMHILMRLNLKKLP-NITKPISVPQNIID--NF 240

Human    74 TRDLLQEKASRRAAACER-ERSDEEY------YAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSL 131
            .||.   .||.:.....| |..||.:      |...:    |..||...:...:....:.:|...
  Fly   241 YRDY---NASSKTTVWNRMESIDESHLSINDTYGDHI----MTDFFDESSSSQMQGDDANTVNEF 298

Human   132 C-------SRQSQV-----------LCGYLDAIP--PTFYRPYFR------IVRFDVSAMEKNAS 170
            .       :::|.:           :..::.:|.  |...:|:.|      :.||.:   :.:.|
  Fly   299 LIDLNKNQAKKSDIPINTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQI---DSSYS 360

Human   171 NLVKAEFRVF-------------RLQNPKARVPEQRI--ELYQILKSKDLTS--PTQRYIDSKVV 218
            :|..|...::             .|:..| :.|.:.|  .:::.::..:.||  |..:..:.:..
  Fly   361 DLSYATLHLYLRGWDWISAHQPGLLEEIK-KQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHS 424

Human   219 KTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDG 283
            .....|:|::.|:...:        .|||                    .|.::|:.     |.|
  Fly   425 IPSGLGQWVAVDLKSLL--------GNLG--------------------SNMTQEIL-----IKG 456

Human   284 TSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRA-LDAAYCFRNVQD-NCC 346
            ..|:    .|::..| ..|:.|.|     |.....:.||:.:|||:.. :|   |..|..| .||
  Fly   457 AETW----MKSLVVT-TDNTSKNP-----LTVHIEIGSQKKHRRKRSVYMD---CTENDHDMRCC 508

Human   347 LRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQ 411
            ..||.::| ...||.::..|..::|.||:|.|...:.....|:.:.:|      ..||:|||...
  Fly   509 RYPLKVNF-TSFGWHFVVAPTSFDAYFCSGDCKVGYLEQYPHTHLAAL------TTSATPCCSPT 566

Human   412 DLEPLTILYY-IGKTPKIEQLSNMIVKSCKCS 442
            .:..|::||: ......:..:.||.|:.|.||
  Fly   567 KMSSLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB2	NP_001129071.1	TGFb_propeptide	21..256	CDD:480997	50/293 (17%)
		TGF_beta_TGFB2	345..441	CDD:381655	27/96 (28%)
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	27/97 (28%)