Protein Alignment TGFB2 and mav

DIOPT Version :10

• Sequence 1: NP_001129071.1
• Gene: TGFB2 / 7042
• HGNCID: 11768
• Length: 442
• Species: Homo sapiens
• Sequence 2: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 79/296 - (26%)
• Similarity: 124/296 - (41%)
• Gaps: 67/296 - (22%)

Human   183 QNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVV---KTRAEGEWLSFDVTDAVHEWLHHKDR 244
            |:.|....:..:::||:|.:......|.|.|:...|   :||.  :|:.||||.||..||:....
  Fly   437 QSNKNSSQQLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRT--QWIEFDVTKAVRSWLNKSHE 499

Human   245 NLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHL 309
            |||  |.:.|..|..:.:.  |:.:.|.....|       ||.:|.:                ||
  Fly   500 NLG--IEIQCDKCKSIGAR--ILSDFSPSTPPR-------STASSDE----------------HL 537

Human   310 LLM----LLPSYRLESQQ-----------TNRRKKRAL------DAAY--------CFRNVQDNC 345
            .||    ::....|.|||           ||.|..:.:      |:.:        |:: :...|
  Fly   538 NLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYK-LHQRC 601

Human   346 CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVS 410
            |...|.:.||...|:::|.:||.::|.:|.|.||...:....|:.:.||....:.:.:..|||..
  Fly   602 CRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPRHNPAHHHALLQSLIWQEDHKRAPRPCCTP 666

Human   411 QDLEPLTILY----YIGKTPKIEQLSNMIVKSCKCS 442
            ..||.|.||:    :..|. ||...|:|.|..|.||
  Fly   667 SKLEMLEILHVDENHSDKL-KISTWSDMQVVECACS 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB2	NP_001129071.1	TGFb_propeptide	21..256	CDD:480997	25/75 (33%)
		TGF_beta_TGFB2	345..441	CDD:381655	32/99 (32%)
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	25/85 (29%)
		TGF_beta_maverick	598..700	CDD:381633	32/102 (31%)