DRSC/TRiP Functional Genomics Resources

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Protein Alignment Megf10 and NimA

DIOPT Version :9

Sequence 1:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus
Sequence 2:NP_001285918.1 Gene:NimA / 318930 FlyBaseID:FBgn0261514 Length:565 Species:Drosophila melanogaster


Alignment Length:195 Identity:66/195 - (33%)
Similarity:91/195 - (46%) Gaps:8/195 - (4%)


- Green bases have known domain annotations that are detailed below.


Mouse    21 GTASSLNLEDP-NVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGE 84
            |..:..:::.| |:|...|.|...||.....|......:.|.:|..  :|...:...|...|..:
  Fly    40 GVVALPSIQGPGNICIREEPYVEHVQVPEMQPVRVRTSSWCMEIPP--RCATFKTEMREVMRVQK 102

Mouse    85 KTMYRRKSQCCPGF----YESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWG 145
            ....|....||.|:    .:|:..|.|.|...|..|.|:.|:.|.||.|:.|.:|:..||.|.||
  Fly   103 LNKTRTVRFCCQGYEGNLSDSQATCKPICRGGCGRGSCVMPDICSCEEGYIGKHCTQRCDHDRWG 167

Mouse   146 PHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGEC 210
            ..|.:.|||:|.|.|:..:|.|||.||:.|..||..|.|||||..|.:.|.|.. ..|:..||.|
  Fly   168 LDCKNLCQCQNGAACDNKSGLCHCIAGWTGQFCELPCPQGTYGIMCRKACDCDE-KPCNPQTGAC 231

Mouse   211  210
              Fly   232  231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 66/195 (34%)
EMI 32..99 CDD:284877 16/70 (23%)
EGF_CA 281..326 CDD:304395
EGF_CA 542..587 CDD:304395
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
NimANP_001285918.1 EMI 52..116 CDD:284877 15/65 (23%)
EGF_2 170..200 CDD:285248 14/29 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D561378at2759
OrthoFinder 1 1.000 - - FOG0001631
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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