DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TGFB1I1 and Pax

DIOPT Version :9

Sequence 1:	NP_001035919.1	Gene:	TGFB1I1 / 7041	HGNCID:	11767	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	226/572 - (39%)
Similarity:	296/572 - (51%)	Gaps:	136/572 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     6 ALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYG-----HQP---------QTGSGESSGASGD- 55
            |||:||:.:.            |.:|..|.|.||     ||.         ..|.|...|.:..
  Fly    30 ALLADLQNSV------------PGQPQQPQPQYGTVQPKHQALQQQQFVDNTPGYGSLRGKAQPQ 82

Human    56 --KDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLG---------------TGLCELDRLLQELN-- 101
              ::| ||.  :.|||    .|...|:.||...|               |||.|||.|||:|.
  Fly    83 VYQEH-YSV--ETRSP----TAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKI 140

Human   102 ---------ATQFNI------------TDEIMSQF------------------------------ 115
                     .:::|.            .|.::.:.
  Fly   141 DVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRET 205

Human   116 -------PSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNH 173
                   |...|.:.|::..|.:|...|: .:.|...:.:|..:.||.|||.||||||||:|.|.
  Fly   206 KTEKLTGPDGPVGTVEEQIVQQKDSYTPN-HAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNG 269

Human   174 LPASG-PTQPPVVSST------------NEGSPSP-----------PEPTGKGSLDTMLGLLQSD 214
            ....| .:.|...|||            |:||...           .|.:.:..||:|||.||::
  Fly   270 TNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQAN 334

Human   215 LSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECY 279
            :||:||.|..||.|.:|.|||.|||:||||:.||||||.|..||..||..:|||:||.|:|...|
  Fly   335 MSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDY 399

Human   280 FERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAP 344
            ...|||||.:||..|..|.||||...||.|||.|..||:.||:||||||:|:||||.|:.::|||
  Fly   400 HNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAP 464

Human   345 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCG 409
            :|.||...|::||||||::.|||||||||:|..||.|||||:|||.|.||.|:||:||||||.|.
  Fly   465 KCNGCNRAIMENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCS 529

Human   410 LPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461
            .|:||||::|:.::|||:||.|.|||:.|.||:|:|:..||||..||.|:||
  Fly   530 KPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIFG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TGFB1I1	NP_001035919.1	Interaction with PTK2B/PYK2	1..240		92/349 (26%)
		Transcription activation. /evidence=ECO:0000250	1..200		71/309 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87		26/97 (27%)
		LD motif 1	3..15		5/8 (63%)
		Interaction with PTK2/FAK1. /evidence=ECO:0000250	83..136		19/127 (15%)
		Paxillin	<86..>106	CDD:308898	11/45 (24%)
		LD motif 2	92..104		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..152		8/35 (23%)
		LD motif 3	157..168		9/10 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..205		10/56 (18%)
		LD motif 4	203..215		7/11 (64%)
		LIM1_Paxillin_like	228..280	CDD:259830	30/51 (59%)
		LIM2_Paxillin_like	287..338	CDD:188723	30/50 (60%)
		LIM3_Paxillin	346..398	CDD:188793	34/51 (67%)
		LIM4_Leupaxin	405..456	CDD:188796	27/50 (54%)
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	30/51 (59%)
		LIM2_Paxillin_like	407..458	CDD:188723	30/50 (60%)
		LIM3_Paxillin_like	466..518	CDD:188724	34/51 (67%)
		LIM4_Paxillin	525..576	CDD:188795	27/50 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1093
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790