Protein Alignment TGFB1 and scw

DIOPT Version :9

• Sequence 1: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 437
• Identity: 92/437 - (21%)
• Similarity: 156/437 - (35%)
• Gaps: 123/437 - (28%)

Human    27 AAGLSTCKT----IDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP--PGPLPEAVLALYNSTR 85
            ||..:|..|    |:|.:.:::.:.. :.:::..|.|...|.:...|  .....:.:|.:||..
  Fly    13 AASATTYVTTNNHIEMPIYQKRPLSE-QMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEI- 75

Human    86 DRVAGESAEPEPEPEADYYAKEVTR-----------VLMVETHNEIYDKFKQSTHSIYMF----- 134
                  |.:.||        |||..           ::..|...||     .|.:||..|
  Fly    76 ------SEDQEP--------KEVLHQRHKRSLDDDILISNEDRQEI-----ASCNSILTFSSRLK 121

Human   135 -------------FNTSELREAVPEPVLLSRAELRLLRLKLKVEQH----VELYQKYSNN---SW 179
                         |||::    ||..:.|.:|.||:.:....|::.    |.:|:|..|.   |:
  Fly   122 PEQLDNELDMHITFNTND----VPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQDFSY 182

Human   180 RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDIN------- 237
            |.|.: :...|....||.|::|..:|.||...|.             .|.|.|::.|.
  Fly   183 RILGS-VNTTSSQRGWLEFNLTDTLRYWLHNKGL-------------QRRNELRISIGDSQLSTF 233

Human   238 -AGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSST----------- 290
             ||..|.:....:.     .||::......|....:|..|.:|.|:.......:
  Fly   234 AAGLVTPQASRTSL-----EPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDL 293

Human   291 ---EKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYS--------KVLALY 344
               .::|......:||::.....|:..||.:.|.||.|.|.:  .|.|:.:        .::.|.
  Fly   294 YRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNF--PLGTKMNATNHAIVQTLMHLK 356

Human   345 NQHNPGASAAPCCVPQALEPLPIVYYVGRK-PKVEQLSNMIVRSCKC 390
            ..|.|    .|||||..|..:.|:.|:... ..:.:....:.:.|.|
  Fly   357 QPHLP----KPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:395559	59/281 (21%)
		TGF_beta_TGFB1	293..391	CDD:381654	26/107 (24%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	55/257 (21%)
		TGFB	300..400	CDD:214556	26/106 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810