Protein Alignment TGFB1 and daw

DIOPT Version :10

• Sequence 1: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 401
• Identity: 98/401 - (24%)
• Similarity: 168/401 - (41%)
• Gaps: 79/401 - (19%)

Human    27 AAGLSTCKT------IDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP-PGPLPEAVLALY--N 82
            |.|...|::      |..|.:...|||.::.|||.||||...|....|. |.|:.:.:...:  :
  Fly   227 AGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAVELPKPIFDGMTLSHPDD 291

Human    83 STRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEP 147
            ||:::...           ||||:...:.:::.......::.:....:..|.| |.::.:|..|.
  Fly   292 STKNKELD-----------DYYARTSKKFILLNREEVECNRARDGKSNPSMCF-TFKIDDADAEG 344

Human   148 VLLSRAELRLLRLKLK----------------VEQHVELYQKYSNNSWRYLSN----RLLAPSDS 192
            ..:|.|.|.|.:.|..                |...||:.|:..:   :|||.    .:.:.:..
  Fly   345 FDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDS---KYLSAAKTIAIQSVNVQ 406

Human   193 PEWLSFDVTGVVRQWLSRGGEIEGFRLSAHC-SCDSRDNTLQVDINAGFTTGRRGDLATIHGMNR 256
            .||:..|:...::.|:| |.|:... :...| .||..|....:.::..:               |
  Fly   407 DEWMKIDIEWPIKHWIS-GHELSHL-IQITCGGCDVSDMEEIISVDKDY---------------R 454

Human   257 PFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGW-KWIHEPKGYHA 320
            ||::     ::.....:.||.:|:::   | ||....||...|||.|| |:|| .||.:|:||:|
  Fly   455 PFIV-----IDMQNRRRKSRQKRSIN---C-SSGMTECCREHLYISFR-DIGWSNWILKPEGYNA 509

Human   321 NFCLGPCPYIWSLD---TQYSKVLALYNQH--NPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQ 379
            .||.|.|..:.|:.   :.:|.::.:.:..  |......|||..:....|.:|.. ......|:.
  Fly   510 YFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKT 574

Human   380 LSNMIVRSCKC 390
            |.||:|.||.|
  Fly   575 LPNMVVESCGC 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:459906	54/261 (21%)
		TGF_beta_TGFB1	293..391	CDD:381654	36/105 (34%)
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	35/102 (34%)