Protein Alignment TGFB1 and dpp

DIOPT Version :10

• Sequence 1: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 104/459 - (22%)
• Similarity: 163/459 - (35%)
• Gaps: 137/459 - (29%)

Human    31 STCKTIDME---LVKRKRIEAIRGQILSKLRLASP-PS--------QGEVPPGP-----LPEAVL 78
            |:.::|.:|   ||..:.:.:|.....:|..:|.. ||        :.::.|.|     :.:::|
  Fly   167 SSIESIFVEEPTLVLDREVASINVPANAKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLL 231

Human    79 ALYNSTRDRVAGESAEPEPEPEADYYAK----EVTRV------LMVETHN----------EIYDK 123
            :|:|..|......|....|||....||:    |:..|      |:.::.|          :|.|:
  Fly   232 SLFNMKRPPKIDRSKIIIPEPMKKLYAEIMGHELDSVNIPKPGLLTKSANTVRSFTHKDSKIDDR 296

Human   124 FKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRY------- 181
            |... |...:.|:.    :::|....|..|||:|.|..|  .|.| :..:.|.|..||
  Fly   297 FPHH-HRFRLHFDV----KSIPADEKLKAAELQLTRDAL--SQQV-VASRSSANRTRYQVLVYDI 353

Human   182 --------------LSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGF--------------- 217
                          |.:......:|.:.:|.||...|.:||:......|.
  Fly   354 TRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPH 418

Human   218 ---RL-----SAH------------CSCDSRDNTLQV-DINAGFTTGRRGDLATIHGMNRPFLLL 261
               ||     .||            .:.|.|.....: |::.|...|:.|     ....:|
  Fly   419 HHVRLRRSADEAHERWQHKQPLLFTYTDDGRHKARSIRDVSGGEGGGKGG-----RNKRQP---- 474

Human   262 MATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGW-KWIHEPKGYHANFCLG 325
             ..|..|..|                   :..|....||:|| .|:|| .||..|.||.|.:|.|
  Fly   475 -RRPTRRKNH-------------------DDTCRRHSLYVDF-SDVGWDDWIVAPLGYDAYYCHG 518

Human   326 PCPYIWS---LDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVR 386
            .||:..:   ..|.::.|..|.|..|||.....||||..|:.:.::|...:...| :....|.|.
  Fly   519 KCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVV 583

Human   387 SCKC 390
            .|.|
  Fly   584 GCGC 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:459906	65/324 (20%)
		TGF_beta_TGFB1	293..391	CDD:381654	36/103 (35%)
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	46/226 (20%)
		TGF_beta_DPP	480..588	CDD:381662	38/128 (30%)