DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFRC and CG10073

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	83/447 - (18%)
Similarity:	148/447 - (33%)	Gaps:	122/447 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   233 VHANFGT-KKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYM------------- 283
            |.:.|.| |....|  .|:..::....:.||...|:........|.|.|::.
  Fly     5 VRSRFDTCKNKISD--EPIEDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFY 67

Human   284 ---------DQTK--FPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTI 337
                     |.:|  |....|:.:.:..|.:||                   :..|..|...:|:
  Fly    68 RIPTGLTIEDASKGVFIAERAQSNLYKLAEIGT-------------------KVVGSDNNENKTV 113

Human   338 SRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDH- 401
            .....  |...::.:|..|: .|....:.......:..|:.|:.:.::  ||  |||  :.|.:
  Fly   114 DYLMG--LVNEIQENCLDDY-FDIEVDLQEVSGSYIHWTMVNMYQGVQ--NI--VIK--LSPKNT 169

Human   402 ----YVVVGAQRDA--WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSA----- 455
                |::|.:..|:  ..|.|..:|.....:|::.::...  .|...:  ..::|....|
  Fly   170 TSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCS--TKQAIR--HPVVFLLNGAEENPL 230

Human   456 -GDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPV-- 517
             ...|.:...:|.:        .....:|||.|..|.|:......|....|:||..:|..|.:
  Fly   231 QASHGFITQHKWAK--------NCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLAT 287

Human   518 --------TGQFLYQDSNWASKVE---KLTLDNAAF--------PFLAYSGIPAVSFCFCEDTDY 563
                    || .|..|:::|..|:   .:.||.|.|        .:..:|.||..|
  Fly   288 TMAEEIFQTG-ILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGS--------- 342

Human   564 PYLGTTMDTYKELIERIPELNKVARAAA---------EVAGQFVIKLTHDVELNLDY 611
              :..|.|....|:..|....::....|         :|.|.:.|..|....:.|:|
  Fly   343 --IQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNGVILNY 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	26/168 (15%)
		M28_TfR	385..610	CDD:193572	53/267 (20%)
		Ligand-binding	569..760		11/52 (21%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	67/358 (19%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	83/447 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900