DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFRC and CG10062

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	68/343 - (19%)
Similarity:	124/343 - (36%)	Gaps:	85/343 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   309 YTPGFPSF-------------NHTQFPPSRSSGLPNIPVQTISRAAAEKLF----------GNME 350
            |.|.|..|             ||...|.:||....: |...|::.|.:.|.          |:|.
  Fly    23 YAPAFFGFWLVLYLSLVNTQMNHMPRPLTRSDEASH-PNSFIAQRAEDTLIELTRIGPRVVGSMA 86

Human   351 GDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKI--------------LNIFGVIKGFV---- 397
            .:       :|....:.:|...|:..:|::| ||::              :|::..|:..|
  Fly    87 NE-------ESAVEFLRAEVAKVESEMSDLL-EIEVDVQQASGAYMHWEMVNMYQGIQNVVVKLS 143

Human   398 ----EPDHYVVVGAQRDA--WGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAG 456
                ..::|:::.:..|:  ..|||...|.....:|::.:    ::.|.|...:..|:|....|.
  Fly   144 EKNSTNENYLLINSHYDSVPGSPGAGDDGSMVVTMLEVMR----VIAKSGDPLAHPIVFLFNGAE 204

Human   457 DFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VT 518
            :.....:..::..:..:.:.||.  ||||.|..|.......:.| .:..:....:||.||   ..
  Fly   205 ENPLQASHAFITQHKWAKNCKAL--INLDSAGSGGREILFQSGP-NHPWLMNYYRNVPHPFANTL 266

Human   519 GQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPEL 583
            .:.|:|.....|       |.....|..|.|:|.:      |..|.:.|....|      :...:
  Fly   267 AEELFQAGYIPS-------DTDFRIFRDYGGVPGL------DMAYIFNGYVYHT------KYNRI 312

Human   584 NKVARAAAEVAGQFVIKL 601
            |...||:.:..|..|:.|
  Fly   313 NAFPRASFQHTGDNVLSL 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	18/90 (20%)
		M28_TfR	385..610	CDD:193572	46/244 (19%)
		Ligand-binding	569..760		7/33 (21%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	59/306 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900