DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFRC and CG13160

DIOPT Version :9

Sequence 1:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens
Sequence 2:	NP_001260918.1	Gene:	CG13160 / 36343	FlyBaseID:	FBgn0033720	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	51/262 - (19%)
Similarity:	97/262 - (37%)	Gaps:	63/262 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   333 PVQTISRAAAE------KLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLK------EIK 385
            |.|.::..|.|      :|...:.||..::   .:...::.:|.:.|:    .||:      |::
  Fly    71 PGQFVAERAQEILLQISRLGPRVVGDVDNE---VTVVNLLLAEIEKVR----QVLRDDVYEMEVE 128

Human   386 ILNIFG--VIKGFVEPDH--------------------YVVVGAQRDAWGPGAAKSGVGTALLLK 428
            :....|  :|||..  :|                    |::|.:..|. .||:..:|...|:::.
  Fly   129 VQRASGSYLIKGLT--NHYQGVQNVIVRLSTKSSNSTSYLLVNSHYDT-KPGSPGAGDDAAMVVV 190

Human   429 LAQMFSDMVLKDGFQPSRSIIFASWSA------GDFGSVGATEWLEGYLSSLHLKAFTYINLDKA 487
            :.::.. :|...|......|||....|      |..|.:....|      :.:.||.  :|||.|
  Fly   191 MLEVLR-LVAVSGDPFLHPIIFLFNGAEEQPMQGSHGFITQHRW------AANCKAL--LNLDSA 246

Human   488 VLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE-KLTLDNAAFPFLAYS 548
            ..|..:......|....|:|....:..||   .|.:.:::.....|..: ::..|....|.|..:
  Fly   247 GAGGRDLLFQGGPNHPWLMEHYRNSAPHPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMA 311

Human   549 GI 550
            |:
  Fly   312 GV 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	9/49 (18%)
		M28_TfR	385..610	CDD:193572	39/198 (20%)
		Ligand-binding	569..760
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:193497	51/262 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900