Protein Alignment TFRC and CG13160

DIOPT Version :10

• Sequence 1: NP_003225.2
• Gene: TFRC / 7037
• HGNCID: 11763
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_001260918.1
• Gene: CG13160 / 36343
• FlyBaseID: FBgn0033720
• Length: 875
• Species: Drosophila melanogaster
• Alignment Length: 262
• Identity: 51/262 - (19%)
• Similarity: 97/262 - (37%)
• Gaps: 63/262 - (24%)

Human   333 PVQTISRAAAE------KLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLK------EIK 385
            |.|.::..|.|      :|...:.||..::   .:...::.:|.:.|:    .||:      |::
  Fly    71 PGQFVAERAQEILLQISRLGPRVVGDVDNE---VTVVNLLLAEIEKVR----QVLRDDVYEMEVE 128

Human   386 ILNIFG--VIKGFVEPDH--------------------YVVVGAQRDAWGPGAAKSGVGTALLLK 428
            :....|  :|||..  :|                    |::|.:..|. .||:..:|...|:::.
  Fly   129 VQRASGSYLIKGLT--NHYQGVQNVIVRLSTKSSNSTSYLLVNSHYDT-KPGSPGAGDDAAMVVV 190

Human   429 LAQMFSDMVLKDGFQPSRSIIFASWSA------GDFGSVGATEWLEGYLSSLHLKAFTYINLDKA 487
            :.::.. :|...|......|||....|      |..|.:....|      :.:.||.  :|||.|
  Fly   191 MLEVLR-LVAVSGDPFLHPIIFLFNGAEEQPMQGSHGFITQHRW------AANCKAL--LNLDSA 246

Human   488 VLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVE-KLTLDNAAFPFLAYS 548
            ..|..:......|....|:|....:..||   .|.:.:::.....|..: ::..|....|.|..:
  Fly   247 GAGGRDLLFQGGPNHPWLMEHYRNSAPHPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMA 311

Human   549 GI 550
            |:
  Fly   312 GV 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFRC	NP_003225.2	Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	9/49 (18%)
		M28_TfR	364..610	CDD:349946	44/225 (20%)
		Ligand-binding	569..760
		TFR_dimer	637..750	CDD:461238
		Cell attachment site, required for binding to transferrin	646..648
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:349872	51/262 (19%)