Protein Alignment TFPI and Tfpi

DIOPT Version :9

• Sequence 1: NP_001316168.1
• Gene: TFPI / 7035
• HGNCID: 11760
• Length: 304
• Species: Homo sapiens
• Sequence 2: NP_001342200.1
• Gene: Tfpi / 21788
• MGIID: 1095418
• Length: 306
• Species: Mus musculus
• Alignment Length: 311
• Identity: 181/311 - (58%)
• Similarity: 222/311 - (71%)
• Gaps: 18/311 - (5%)

Human     1 MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKA 65
            |.|.|||.:|.||:|||||:|.|..|||.|||.::    ||:||..:|.:|:|||.|||||||||
Mouse     1 MTYKMKKEYAFWATVCLLLSLVPEFLNALSEEADD----TDSELGSMKPLHTFCAMKADDGPCKA 61

Human    66 IMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEED 130
            :::.:|||::|.|||||||||||||:|||::||||||.|........:|.....|:|||||||||
Mouse    62 MIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTCIPGYEKTAVKAASGAERPDFCFLEED 126

Human   131 PGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICED-----GP-NGFQVDNYGT 189
            ||:||||:.||.|||||||||||.|||||||.||||||:|||.|||:     .| |..|:.:|.|
Mouse   127 PGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICENPVHSPSPVNEVQMSDYVT 191

Human   190 QLN------AVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYS 248
            ..|      .|||.:.|||.|||...::.|..|||.|||.|||:|:|.||||||..|||..|.|:
Mouse   192 DGNTVTDRSTVNNIVVPQSPKVPRRRDYRGRPWCLQPADSGLCKASERRFYYNSATGKCHRFNYT 256

Human   249 GCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEI 299
            |||||.||||:::.|||:||.|.|:..|| |::|.:| ||...||:.||.|
Mouse   257 GCGGNNNNFTTRRRCLRSCKTGLIKNKSK-GVVKIQR-RKAPFVKVVYESI 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFPI	NP_001316168.1	Kunitz_BPTI	53..104	CDD:278443	38/50 (76%)
		KU	123..175	CDD:238057	43/51 (84%)
		Kunitz_BPTI	216..268	CDD:278443	34/51 (67%)
Tfpi	NP_001342200.1	KU	48..101	CDD:238057	38/52 (73%)
		Kunitz_BPTI	120..171	CDD:394972	42/50 (84%)
		Kunitz_BPTI	224..276	CDD:394972	34/51 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965845
Domainoid	1	1.000	109	1.000	Domainoid score	I43186
eggNOG	1	0.900	-	-		E1_KOG4295
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4579
Inparanoid	1	1.050	374	1.000	Inparanoid score	I14074
Isobase	1	0.950	-	0	Normalized mean entropy	S6653
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41373
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000145
OrthoInspector	1	1.000	-	-		oto115036
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X897
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.310