Protein Alignment TFE3 and RTG3

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_009447.1
• Gene: RTG3 / 852171
• SGDID: S000000199
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 547
• Identity: 121/547 - (22%)
• Similarity: 194/547 - (35%)
• Gaps: 171/547 - (31%)

Human    51 ADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATP-----ATLSASSSAGGSRTPAMSSSS 110
            ::.|.:.:||     ||.:|...|:.:|..|| .|| ||     ..:..|:..|| .|||.....
Yeast     7 SEAENQRLLD-----ELMNQTKVLQETLDFSL-VTP-TPHHNDDYKIHGSAYPGG-ETPAQQHEK 63

Human   111 SSRVLL-----RQQLMRAQAQEQ----------ERRERREQAAAAPFPSPAPASP----AISVVG 156
            .|.:..     ...||.:||:..          |..|.:.......|.:.....|    :||.:|
Yeast    64 LSYINTHNSNDNNNLMGSQARSNSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQNSISSIG 128

Human   157 VS--AGGHTLSRPPP----------------AQVPREVLKVQTHLENPTRYHLQQARRQQVKQYL 203
            ..  ...::::...|                |::|.:.|  ..|..:.|.|:|...        |
Yeast   129 QGPLRSSYSMAYDSPVDRAMNTPLQQQEGLKAELPHDFL--FQHGTDDTMYNLTDD--------L 183

Human   204 STTLGPKLASQALTPPP------------GPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSS 256
            |::|...:.|..:||..            ||||.....:|:.           .||.:....||
Yeast   184 SSSLSSSINSDMMTPNTYSSSFSYNPQSLGPASVSSTYSPKV-----------RSPSSSFRAGS- 236

Human   257 SEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPST--LPVSGNLLDVYSSQGVATPAITVS 319
                         .|.||:..          ..:..|.|  ..:|.|:.:
Yeast   237 -------------FLSSSFRH----------GSINTPRTRHTSISSNMTE--------------- 263

Human   320 NSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKS------SD 378
            |..|..:|.|...::..|     |.|:|::.||.:|||||..|..:|||||.|:|.|      ..
Yeast   264 NIGPGSVPKILGGLTSDE-----KLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLG 323

Human   379 PEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPP 443
            .:::.|||.||..:|:|::.|      ::.||.:.|.    .::|..:|:|||.:........|.
Yeast   324 KQIKPNKGIILDRTVEYLQYL------AEILEIQARK----KKALLAKIKELEEKKSSVAALSPF 378

Human   444 TPGLLSLATTSASDSLKPEQLDIEEEGRPGA--------ATFHVGGGPAQNAPHQQPPAPPSDAL 500
            |..  ..|::..::|...|:..|:....|.|        |..|          :.:||      |
Yeast   379 TNN--HHASSGQNNSENSEERIIDIRSVPNALMNEQNSKAELH----------NWEPP------L 425

Human   501 LDLHFPSDHLGDLGDPFHLGLEDILME 527
            .|.....:|.|.:....|..:.:.|.|
Yeast   426 YDSVGNHNHAGTMESHPHTNIHEELKE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	23/128 (18%)
		bHLHzip_TFE3	337..427	CDD:381498	32/95 (34%)
		DUF3371	432..573	CDD:463372	19/104 (18%)
RTG3	NP_009447.1	bHLHzip_USF_MITF	289..349	CDD:381393	24/65 (37%)