Protein Alignment TFE3 and tfe3b

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_001038531.1
• Gene: tfe3b / 564996
• ZFINID: ZDB-GENE-010919-3
• Length: 451
• Species: Danio rerio
• Alignment Length: 491
• Identity: 276/491 - (56%)
• Similarity: 338/491 - (68%)
• Gaps: 69/491 - (14%)

Human   111 SSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTL----SRPPPAQ 171
            ||||||||||||.|||||||||.::||:.|.. .||..:|||||        :|    :||||||
Zfish     2 SSRVLLRQQLMREQAQEQERREAQQQASVAQL-RPADTTPAISV--------SLPPMAARPPPAQ 57

Human   172 VPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHT 236
            ||.|||||||||||||:||:|||:|||||:|||||||.|:|:|.|...|.|.||.   |||
Zfish    58 VPVEVLKVQTHLENPTKYHIQQAQRQQVKEYLSTTLGNKVATQTLGVSPVPHSAS---APE---- 115

Human   237 TGPT-GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG 300
            .||: .||||||||.|.:||:.| |:|||||:|||||||:||::||.:   .:|||||:|||  |
Zfish   116 MGPSASSAPNSPMAHLNLGSNKE-EMDDVIDDIISLESSFNDDILSLI---DSGLQLPNTLP--G 174

Human   301 NLLDVYSSQGVATPAITVSNSCPAELPNIKRE------ISETEAKALLKERQKKDNHNLIERRRR 359
            ||||||:|.|:.||.|||||||||:|||||||      :.||||:|.:|||||||||||||||||
Zfish   175 NLLDVYNSPGMTTPTITVSNSCPADLPNIKREYTGNVIVIETEARAFMKERQKKDNHNLIERRRR 239

Human   360 FNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQ 424
            |||||||||||.|||||:||||||||||||||||||||||||||||:|::|.||:.|||:|::|.
Zfish   240 FNINDRIKELGALIPKSTDPEMRWNKGTILKASVDYIRKLQKEQQRAKEIEMRQKKLEQSNQALI 304

Human   425 LRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPE---QLDIEEEGRPGAATFHVGGGPAQN 486
            |||||||:||:.|||....:|||.:.|:...:..|:|.   |..: .:|:| .:..::.|..||.
Zfish   305 LRIQELEIQARHHGLNATVSPGLNTEASFIQNQLLQPNASMQAGV-GDGQP-QSHLNMDGAMAQT 367

Human   487 APHQQPPAPPSDALL------DLHFPS-------DHLGDLGDPFHLGLEDILMEEEEGVVGGLSG 538
            :|......|||.:..      .||..:       :|..||..  .:||.||||::..|
Zfish   368 SPSPFLSVPPSGSPAAVAVSGPLHLETFSFTELDEHASDLYP--DVGLSDILMDDVRG------- 423

Human   539 GALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEE 574
                     ||.|.|.:||..||.||:.||.:||::
Zfish   424 ---------SDVLFSPMSPGASKTSSQGSSINMEDD 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	67/101 (66%)
		bHLHzip_TFE3	337..427	CDD:381498	74/89 (83%)
		DUF3371	432..573	CDD:463372	46/156 (29%)
tfe3b	NP_001038531.1	MITF_TFEB_C_3_N	4..145	CDD:464952	97/157 (62%)
		bHLH_SF	217..307	CDD:469605	74/89 (83%)
		DUF3371	312..450	CDD:463372	47/157 (30%)