DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TFE3 and Mitf

DIOPT Version :9

Sequence 1:	NP_006512.2	Gene:	TFE3 / 7030	HGNCID:	11752	Length:	575	Species:	Homo sapiens
Sequence 2:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	787	Identity:	212/787 - (26%)
Similarity:	302/787 - (38%)	Gaps:	265/787 - (33%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSHAAEPARD-----------GVEASAEGPRAVFV-------LLEERRPAD-SAQLLSLNSLLPE 46
            |||  ..:||           .:|...|.|...|.       .|...|.:| ....|.:.::...
  Fly    64 MSH--NESRDLVNGPNICSSMDIEVGEEPPTTSFADNIDKACPLPVLRSSDCDCVPLCMTNIRVS 126

Human    47 SGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSS- 110
            .||..|:|:...:|| |..:|..          ||:..| |.|..:.....:||   |...:::
  Fly   127 VGIDKDLEMILEMDP-SIVDLGD----------ISIDET-AEPRIVGLPPLSGG---PTFKTATP 176

Human   111 SSRVLLRQQLMRAQAQEQERRERREQAAAAP------------FPSPAPASPAISVVGV------ 157
            :||..|:.||.|.|.|:...:::....|..|            ..|....|.:.|..|.
  Fly   177 TSRTQLKLQLQREQQQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLE 241

Human   158 -------------SAGGHTLSRPPPA---QVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTT 206
                         |:.|..|..|..:   .||.:||:|.|.||||||||:.|.::.||:||||.:
  Fly   242 QMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSES 306

Human   207 LGP----------KLASQA--------------------------------------------LT 217
            ..|          |||:.:                                            ::
  Fly   307 FKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPIS 371

Human   218 P------------PPGPASAQP----LPAPEAAHTTGPTG-SAPNSPMALLTIGSSSEKEIDDVI 265
            |            |..|...:|    ...||.||.|...| |..||.:       ||.:....::
  Fly   372 PFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSL-------SSTRSSSGIV 429

Human   266 DEI-ISLESSYNDEMLSYLPGGTTGLQLPST-LPVSGNLLDVYSSQGVATP-----------AIT 317
            :.| ||..||                .|.|| .|:|.::..|.:|  |:.|           :..
  Fly   430 NSIRISSTSS----------------SLQSTSAPISPSVSSVATS--VSEPDDIFDDILQNDSFN 476

Human   318 VSNSCPAELPNIKRE---ISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDP 379
            ...:..:|| :||:|   :::.|..||.|:||||||||:|||||||||||||||||||:||.||.
  Fly   477 FDKNFNSEL-SIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDA 540

Human   380 ------EMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHG 438
                  ::|.|||||||:|||||:.|:.|..|.:..|.|||.:|..||.|..||:|||:||:.||
  Fly   541 FYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHG 605

Human   439 ----------LPVPPTPGLLSLA-TTSASDSLK-----PEQLDIE----EEGRPGA--------- 474
                      |..|..|.|.|.: :.:||.|.:     |.:..|:    .:|..|.
  Fly   606 ILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMED 670

Human   475 ATFHVGGGPAQNAPHQQ----PPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGV--- 532
            ..:.|.||....:.|..    |.:|.|..|....|...:..:..:....|...:..::..|:
  Fly   671 CKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCGINCS 735

Human   533 --------------------------VGGLSGGA----LSPLRAASDPLLSSVSPAVSKASSRRS 567
                                      :..||..|    .|.|....|||||         ||.||
  Fly   736 TSCYIQHQLTSREGHPNHSHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLS---------SSHRS 791

Human   568 SFSMEEE 574
            ..:::|:
  Fly   792 LGTVDED 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	113..266	CDD:374248	57/257 (22%)
		bHLHzip_TFE3	337..427	CDD:381498	59/95 (62%)
		DUF3371	432..573	CDD:371761	41/206 (20%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	22/38 (58%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	45/64 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157592
Domainoid	1	1.000	85	1.000	Domainoid score	I8159
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4199
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm40964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860