Protein Alignment TFE3 and Tfe3

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_766060.2
• Gene: Tfe3 / 209446
• MGIID: 98511
• Length: 572
• Species: Mus musculus
• Alignment Length: 575
• Identity: 551/575 - (95%)
• Similarity: 560/575 - (97%)
• Gaps: 3/575 - (0%)

Human     1 MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDPDSFY 65
            ||||||||||.||||||||||||:||||||||:||||||||||||||||||||||||:|||||||
Mouse     1 MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILDPDSFY 65

Human    66 ELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQER 130
            |||||||.|||||||||||||.||||||||||||||||||| |||||||||||||||||||||||
Mouse    66 ELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSRTPAM-SSSSSRVLLRQQLMRAQAQEQER 129

Human   131 RERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQAR 195
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   130 RERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQAR 194

Human   196 RQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKE 260
            |||||||||||||||||||||||||||:|||||||||.||.||||||||||||||||||||||||
Mouse   195 RQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKE 259

Human   261 IDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAE 325
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   260 IDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAE 324

Human   326 LPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILK 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Mouse   325 LPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILK 389

Human   391 ASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSA 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||.|:|.
Mouse   390 ASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSV 454

Human   456 SDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLG 520
            ||||||||||||||||| :.||||.||||||||.|||||||||||||||||||||||||||||||
Mouse   455 SDSLKPEQLDIEEEGRP-STTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLG 518

Human   521 LEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES 575
            |||||| ||||:|||||||||||||||||||||||||||||||||||||||||||
Mouse   519 LEDILM-EEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	97/100 (97%)
		bHLHzip_TFE3	337..427	CDD:381498	88/89 (99%)
		DUF3371	432..573	CDD:463372	129/140 (92%)
Tfe3	NP_766060.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..152		63/65 (97%)
		MITF_TFEB_C_3_N	112..265	CDD:464952	148/152 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..248		34/37 (92%)
		Strong transcription activation domain. /evidence=ECO:0000255	259..270		10/10 (100%)
		bHLHzip_TFE3	336..426	CDD:381498	88/89 (99%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P19532	355..358		2/2 (100%)
		Leucine-zipper	408..429		20/20 (100%)
		DUF3371	431..570	CDD:463372	129/140 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..495		47/56 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..572		41/41 (100%)