Protein Alignment TFE3 and hlh-30

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_001023411.1
• Gene: hlh-30 / 177157
• WormBaseID: WBGene00020930
• Length: 524
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 139/568 - (24%)
• Similarity: 206/568 - (36%)
• Gaps: 218/568 - (38%)

Human   117 RQQLMRAQAQEQ--------------------ERRERREQAAAAPF--------PSPAPASPAIS 153
            :||....|||:|                    ...:|||.....|.        .:|..::|..|
 Worm    28 QQQQQPQQAQQQFYDDEPYQANASQFRFGAGKSMEQRRETGNLIPIAQRSMGSTSTPFGSAPTQS 92

Human   154 VVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTP 218
            ..|..:.|..||.|...|        |||                  |.|...:.|
 Worm    93 YFGGGSSGAALSSPRKMQ--------QTH------------------QMLFGNIQP--------- 122

Human   219 PPGPASAQPLPAPEAAHTTG--PTGSAPNSPMALLTIGSSSEKEIDD-VIDEIISLESSYNDEML 280
               |..:.|....:..|..|  ||...         :|.....|:|| :|||::.:|   :|:.:
 Worm   123 ---PRGSPPSDGSDKIHRFGESPTPGG---------VGGVFGTELDDLIIDELMGME---DDQRM 172

Human   281 SYLPGGTTGLQL--------------------------PSTLP--VSGNLLDVYSSQGVATPAIT 317
            .  ||.|..:.:                          |.|:|  :|.|...|
 Worm   173 R--PGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQV------------ 223

Human   318 VSNSCPAELPNIKREI-----------SETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGT 371
            ||:|.|....:|::.|           .:.:.:...::|:|||.||:||||||:||||||||||.
 Worm   224 VSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQ 288

Human   372 LIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQI 436
            ::||::..:|:.|||||||||.||||.|||:::::...:.:|:|||........|::|||.....
 Worm   289 MLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLAR 353

Human   437 HGLPVPP-------------------------TP--------GLLSLAT--------TSASDSLK 460
            .|:.|||                         ||        |.||..|        ||.:|| :
 Worm   354 QGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDS-R 417

Human   461 PEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPP----SDALLDLHFPSDHLGDLGDPFHLGL 521
            |.  :......|..:.|.||..           :||    |........|..:          ..
 Worm   418 PN--NFMNNSAPSDSFFSVGSA-----------SPPDYRTSSGTASWKLPGSN----------AF 459

Human   522 EDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVS--PAVSKASSRRS 567
            .|::|::...::.|             |||:||..  |:....||:.|
 Worm   460 SDLMMDDLNPMMNG-------------DPLISSAGAHPSPHFHSSQMS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	19/103 (18%)
		bHLHzip_TFE3	337..427	CDD:381498	45/89 (51%)
		DUF3371	432..573	CDD:463372	35/183 (19%)
hlh-30	NP_001023411.1	bHLHzip_MITF_like	260..328	CDD:381403	41/67 (61%)