Protein Alignment TFE3 and tfe3a

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: NP_571923.2
• Gene: tfe3a / 114834
• ZFINID: ZDB-GENE-010919-2
• Length: 539
• Species: Danio rerio
• Alignment Length: 603
• Identity: 321/603 - (53%)
• Similarity: 391/603 - (64%)
• Gaps: 108/603 - (17%)

Human     2 SHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVL--DPDSF 64
            |..|.|.:.|    .|.|:.|:|:|:.   |:|..|:|:..||||||||||||:|:|.  |.|:|
Zfish    14 SEVASPGQQG----HERPQTVYVILDS---AESVNLISVEPLLPESGIVADIEVESVFSADSDAF 71

Human    65 YELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQE 129
            ||||.||:....||   ..|.|.||.                .|..:||||:||:|||.|||:||
Zfish    72 YELKGQPITPSGSL---TSADPVTPT----------------GSVMTSRVLMRQELMRQQAQDQE 117

Human   130 RRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPP--PAQVPREVLKVQTHLENPTRYHLQ 192
            |||.::||::|. .....::|||||.         |..|  |.|||.|||||||||||||:||:|
Zfish   118 RREAQKQASSAQ-QRLTDSTPAISVA---------SNLPAKPTQVPVEVLKVQTHLENPTKYHIQ 172

Human   193 QARRQQVKQYLSTTLGPKLASQAL--TPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGS 255
            ||:|||||||||.|||.|:|||.|  :|||.|:||..| ||.|:       |.|:||:|:|::||
Zfish   173 QAQRQQVKQYLSHTLGNKIASQTLATSPPPQPSSAPEL-APAAS-------STPSSPLAVLSLGS 229

Human   256 SSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSN 320
            :.| ||:||||:|||||||.|||.::.:   .:||||||||||||||||||||||:|.|.|||||
Zfish   230 NKE-EIEDVIDDIISLESSLNDEFMTLI---DSGLQLPSTLPVSGNLLDVYSSQGMAAPTITVSN 290

Human   321 SCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNK 385
            ||||:|.|:|||:|:.||||::|||||||||||||||||||.||||||||.|||||||||:||||
Zfish   291 SCPADLQNVKREMSDAEAKAIMKERQKKDNHNLIERRRRFNTNDRIKELGALIPKSSDPELRWNK 355

Human   386 GTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSL 450
            ||||||||||||||||||||||::|:||:.||.|||||.|||||||:||::||           |
Zfish   356 GTILKASVDYIRKLQKEQQRSKEMETRQKKLEHANRSLMLRIQELEMQARLHG-----------L 409

Human   451 ATTSASDSLKPEQ-LDIEEEGR--------------------PGAATFHVGGGPAQNAPHQQPPA 494
            :::..||||...| |.:|....                    |.::|..|||         ...:
Zfish   410 SSSQLSDSLTQTQTLTLEHNPNTDLSKTLLSITQTTPSSFLSPPSSTSSVGG---------TVTS 465

Human   495 PPSDALLDLHFPSDHLGDLGDP---FHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVS 556
            |.....|......||...:..|   ..:||.||||::         .|||||:..| |||||:||
Zfish   466 PLELGTLSFGELDDHTASVFSPALMADMGLGDILMDD---------SGALSPVGGA-DPLLSAVS 520

Human   557 PAVSKASSRRSSFSMEEE 574
            |..||.|||||||||||:
Zfish   521 PGASKTSSRRSSFSMEED 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	64/104 (62%)
		bHLHzip_TFE3	337..427	CDD:381498	77/89 (87%)
		DUF3371	432..573	CDD:463372	53/164 (32%)
tfe3a	NP_571923.2	MITF_TFEB_C_3_N	101..239	CDD:464952	88/156 (56%)
		bHLHzip_MITF	305..408	CDD:381496	85/102 (83%)
		DUF3371	402..538	CDD:463372	54/165 (33%)