Protein Alignment TFE3 and tfe3

DIOPT Version :10

• Sequence 1: NP_006512.2
• Gene: TFE3 / 7030
• HGNCID: 11752
• Length: 575
• Species: Homo sapiens
• Sequence 2: XP_031747133.1
• Gene: tfe3 / 100490005
• XenbaseID: XB-GENE-5918222
• Length: 516
• Species: Xenopus tropicalis
• Alignment Length: 594
• Identity: 329/594 - (55%)
• Similarity: 381/594 - (64%)
• Gaps: 97/594 - (16%)

Human     1 MSHAAEPARDGVEASA---EGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLDP- 61
            |||..     |.|..|   .....|:||:..  .|||.|||||:.:|||||||.|||:|..::|
 Frog     1 MSHDT-----GCETPALRSPSQHTVYVLVGS--SADSIQLLSLSPILPESGIVPDIEVERAIEPS 58

Human    62 -DSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQA 125
             :.||:|||||:| .|..|   ..||..|.           :||   .:.|||||||||||||||
 Frog    59 ENQFYQLKSQPIP-SSQTP---SETPLVPL-----------QTP---GAMSSRVLLRQQLMRAQA 105

Human   126 QEQERRERREQAA--AAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTR 188
            |||||||:.:|||  .|...:..|.||||:|.       ..:||.|||||.||||||||||||||
 Frog   106 QEQERREQEQQAAQILAERGNLVPPSPAINVT-------PNTRPTPAQVPLEVLKVQTHLENPTR 163

Human   189 YHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTI 253
            ||:||::|||||||||||||.|:...|  ..||.|:....|.||.|.... ..||||||:|:|.|
 Frog   164 YHIQQSQRQQVKQYLSTTLGAKVPMNA--SAPGTAAPGSSPKPEVAPQVS-ASSAPNSPLAMLKI 225

Human   254 GSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITV 318
            |||.|||||||||||||||||:||||:.::...    .|||||||:|||||||....:|||||||
 Frog   226 GSSLEKEIDDVIDEIISLESSFNDEMMGFVERS----HLPSTLPVAGNLLDVYCGASLATPAITV 286

Human   319 SNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRW 383
            ||||||||||||.|.::.||||::||||||||||||||||||||||||||||:|||||||||:||
 Frog   287 SNSCPAELPNIKTEYTDVEAKAMIKERQKKDNHNLIERRRRFNINDRIKELGSLIPKSSDPELRW 351

Human   384 NKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLL 448
            ||||||||||:|||||||||||.::||.||..||..|:||.|||||||:|||:||:...|
 Frog   352 NKGTILKASVEYIRKLQKEQQRVRELEGRQHRLEHMNQSLMLRIQELEMQAQLHGISAAP----- 411

Human   449 SLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLD---LHFPSDHL 510
              ...:.:::||                   |..||...|..|....|....||   ||| :|.|
 Frog   412 --PACNPTNTLK-------------------GAPPAMAMPAFQSAQRPDPTTLDLGTLHF-TDPL 454

Human   511 GDLGDP---FHLGL------EDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRR 566
            .||.|.   |||.|      .||||::           |||||..| |||||||||..||.|||.
 Frog   455 SDLVDQDLNFHLSLTGDSAIADILMDD-----------ALSPLGGA-DPLLSSVSPQASKTSSRH 507

Human   567 SSFSMEEES 575
            ||||||::|
 Frog   508 SSFSMEDDS 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFE3	NP_006512.2	MITF_TFEB_C_3_N	<165..266	CDD:464952	66/100 (66%)
		bHLHzip_TFE3	337..427	CDD:381498	74/89 (83%)
		DUF3371	432..573	CDD:463372	57/152 (38%)
tfe3	XP_031747133.1	MITF_TFEB_C_3_N	93..238	CDD:464952	96/154 (62%)
		bHLHzip_MITF	303..406	CDD:381496	83/102 (81%)
		DUF3371	400..515	CDD:463372	58/153 (38%)