DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TFDP2 and Dp

DIOPT Version :9

Sequence 1:	NP_001362702.1	Gene:	TFDP2 / 7029	HGNCID:	11751	Length:	447	Species:	Homo sapiens
Sequence 2:	NP_477039.1	Gene:	Dp / 36461	FlyBaseID:	FBgn0011763	Length:	445	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	174/407 - (42%)
Similarity:	234/407 - (57%)	Gaps:	63/407 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    47 LPKTLGPINVNVGPQMIISTPQRLTSSGS-----VLIGSPY---TPAP-AMVTQTHIAEATGWVP 102
            :|||      ..|......:.|:.:.:||     .|.|..|   ||.| .|.::.|..::
  Fly    91 IPKT------EAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQS----- 144

Human   103 GDRKRARKFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNN 167
                .:...:.:..|..:|.:|.||.|||||||||||||||:.||.|:||||||:||||...:|
  Fly   145 ----NSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNN- 204

Human   168 HLAADSQAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERI 232
              |.|:.. ||||||||||||||||||:|:|||:||||:|||||.||.:....||.|..:|.|||
  Fly   205 --AYDNNC-DQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERI 266

Human   233 KQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKF 297
            |||...|:|:::|.:|||.||:||::||.|.. .|:.|::|||||||:||.:.|.|:||:::||.
  Fly   267 KQKNEMLREMIMQHVAFKGLVERNKRNESQGV-VPSPNASIQLPFIIVNTHKSTKINCSVTNDKS 330

Human   298 EYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQ 362
            ||:|.||.|||:|||||||||||...||:.|:|:.|:::..||.||..|..|:....||
  Fly   331 EYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTG------ 389

Human   363 GLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPNSHQ--SSSAASHCSESRG 425
                           .||..:.:|        |.|.....|...:.|..|  :..:|.|.::  |
  Fly   390 ---------------KTGENMYES--------DDEDNEFNGYLESANESQGFAQHSAQHTTD--G 429

Human   426 ETPCSFNDEDEEDDEED 442
            |..... |:||.||:.|
  Fly   430 EFKLEM-DDDELDDDID 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFDP2	NP_001362702.1	Interaction with CEBPA. /evidence=ECO:0000269\|PubMed:20176812	60..82		5/26 (19%)
		Nuclear localization signal. /evidence=ECO:0000250	103..118		0/14 (0%)
		E2F_TDP	129..209	CDD:396755	58/79 (73%)
		DEF box	177..211		29/33 (88%)
		coiled coil	214..260	CDD:271217	21/45 (47%)
		DP	216..354	CDD:400917	70/137 (51%)
		Dimerization. /evidence=ECO:0000255	220..293		38/72 (53%)
		DCB1	230..262		18/31 (58%)
		DCB2	275..331		35/55 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..447		11/35 (31%)
Dp	NP_477039.1	E2F_TDP	167..243	CDD:280479	58/79 (73%)
		coiled coil	248..294	CDD:271217	21/45 (47%)
		DP	255..388	CDD:285934	70/133 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140855
Domainoid	1	1.000	147	1.000	Domainoid score	I4514
eggNOG	1	0.900	-	-		E1_KOG2829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2932
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046304at2759
OrthoFinder	1	1.000	-	-		FOG0002399
OrthoInspector	1	1.000	-	-		otm41428
orthoMCL	1	0.900	-	-		OOG6_102647
Panther	1	1.100	-	-	LDO	PTHR12548
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2839
SonicParanoid	1	1.000	-	-		X1414
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790