Protein Alignment NR2F1 and Hr51

DIOPT Version :10

• Sequence 1: NP_005645.1
• Gene: NR2F1 / 7025
• HGNCID: 7975
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_611032.2
• Gene: Hr51 / 36702
• FlyBaseID: FBgn0034012
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 168/546 - (30%)
• Similarity: 218/546 - (39%)
• Gaps: 177/546 - (32%)

Human    38 GEQQQQAGSG-APHTPQTPGQPGAPATP---------------------GTAGDKGQGPPGSGQS 80
            |:......:| ||.|...|..|.||..|                     ..|..........|.|
  Fly    34 GQAPPPTSTGVAPPTQPPPPHPAAPNVPNGRLLSWNHSAAAAAAAAAAQAAANSMNHSSAAEGSS 98

Human    81 QQHIE-------CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANR-NCPIDQHHRNQ 137
            ...|:       ||||||.|||||||...|.||..||||||||.|.|.|:|.. .|.:|:.||||
  Fly    99 MTRIKGQNLGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQ 163

Human   138 CQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN-----------------GDP--LNGHC 183
            ||.|||||||::||.::|||..|.|..........|..                 |.|  |:..|
  Fly   164 CQACRLKKCLQMGMNKDAVQNERQPRNTATIRPETLREMEHGRALREAAVAVGVFGPPVLLSPPC 228

Human   184 YLSGYI---------------------SLLLRA-------------------------------- 195
            |.||.:                     |:.|.|
  Fly   229 YGSGLLPPPSLGSLPTGRLLHHNHLTSSMQLAANHMGAGSFPMFNAAGVHHSPKEKAYGMEMATS 293

Human   196 -------------------------------------------------------------EPYP 199
                                                                         ||:.
  Fly   294 GNVSHSTNSSSNHSIDPSSPAPENAKEINIAGGSVSSVSSSSPTMENDNDDDSIDVTNDNEEPHA 358

Human   200 TSRYGS-----QCMQPN-NIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSE 258
            .||..|     |.|.|| .....|.:.|.:|||||.||:||:|:|.|..|...|||.||..:|||
  Fly   359 VSRSDSSFIMPQFMSPNLYTHQHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSE 423

Human   259 LFVLNAAQCSMPLH-VAPLLAAAGLHASPM----SADRVVA---FMDHIRIFQEQVEKLKALHVD 315
            ||:|||.|..:||. ....|.:...|.:.:    :.|..:.   ....:|...|...|.||:.||
  Fly   424 LFLLNAIQWCIPLDPTGCALFSVAEHCNNLENNANGDTCITKEELAADVRTLHEIFCKYKAVLVD 488

Human   316 SAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTV 380
            .||::||||||||..:..||.|.|.||:||:::...|.::.::|:..|.:|||:|||.||.||.:
  Fly   489 PAEFACLKAIVLFRPETRGLKDPAQIENLQDQAHVMLSQHTKTQFTAQIARFGRLLLMLPLLRMI 553

Human   381 SSSVIEQLFFVRLVGKTPIETLIRDM 406
            ||..||.::|.|.:|.||:|.::.||
  Fly   554 SSHKIESIYFQRTIGNTPMEKVLCDM 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR2F1	NP_005645.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		12/64 (19%)
		NR_DBD_COUP_TF	86..158	CDD:143516	47/72 (65%)
		NR_LBD_COUP-TF	184..419	CDD:132746	99/351 (28%)
Hr51	NP_611032.2	NR_DBD_PNR	103..194	CDD:143528	50/90 (56%)
		NR_LBD_Tlx_PNR_like	354..569	CDD:132748	87/214 (41%)