Protein Alignment TFAP2B and TfAP-2

DIOPT Version :10

• Sequence 1: XP_016866722.1
• Gene: TFAP2B / 7021
• HGNCID: 11743
• Length: 515
• Species: Homo sapiens
• Sequence 2: NP_001262178.1
• Gene: TfAP-2 / 40398
• FlyBaseID: FBgn0261953
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 479
• Identity: 212/479 - (44%)
• Similarity: 272/479 - (56%)
• Gaps: 65/479 - (13%)

Human    61 GDQVLRIREVSLQMLVHTYSSMDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYF 125
            |...|.:...|.....|:.....|......||...|..||.:...:.|.       .||||||||
  Fly    24 GHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSL-------QSDFQPPYF 81

Human   126 PPPYQPLPYHQSQDP---------YSH------VNDPYS--LNPLHQPQQHPWGQ----RQRQ-E 168
            |||:    :|.:|.|         .:|      ..|||.  |:.||....|.:.|    |..| :
  Fly    82 PPPF----HHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQ 142

Human   169 VGSEAGSLLPQPRAALPQLSG----LDPRRDYHSVRRPDVLLHSAHHGLDAG-MGDSLSLHGLGH 228
            :|........:.:..:.|||.    .|.|.||.|     .:...|.||...| ..:||:||....
  Fly   143 LGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGS-----AISAGAAHGTRLGHEHESLALHQALQ 202

Human   229 PGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKD-GFLGGMSVNTGEVFCSVPGRL 292
            ..::|||:         ..||.:|.....:|  .:.|:...|: |.:|  |.:..||||:|||||
  Fly   203 NAVDDVQA---------PALDDNVAFMSDLP--LIKSMKSGKEAGNIG--SGSPSEVFCAVPGRL 254

Human   293 SLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKA 357
            ||||||||||||:.|||||||||||||||||||||||||||||||.|||:|||||||||||||||
  Fly   255 SLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKA 319

Human   358 ANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEF 422
            ||||||||||||||.|||:||.::|||||||:.::||:.|..|:|.|.:.||.::|.::|:.||.
  Fly   320 ANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKEL 384

Human   423 TDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMF 487
            ..:|:||||....:|...:|||.:|..||||||||||||:|||.|.|.|.|.:|.|:|..::|::
  Fly   385 MQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLY 449

Human   488 LNNTTTNRHTSGEGPGSKTGDKEE 511
            .:|        |.|..|.:.||.:
  Fly   450 PSN--------GGGMVSSSLDKSK 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFAP2B	XP_016866722.1	TF_AP-2	285..479	CDD:460877	136/193 (70%)
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:460877	136/193 (70%)