DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TFAP2A and TfAP-2

DIOPT Version :9

Sequence 1:	XP_016866721.1	Gene:	TFAP2A / 7020	HGNCID:	11742	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	218/476 - (45%)
Similarity:	282/476 - (59%)	Gaps:	69/476 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    83 SAHASAG--SNPALYDQDRHDGTSNGTARLPQLGTVG-QSPYTSAPPLSH-TPNADFQPPYFPPP 143
            |.|.|.|  |..|.|  ..|.|...|.:. |..|..| .|.:.||..:.| :..:||||||||||
  Fly    23 SGHGSLGLSSGSAAY--TTHSGGHTGRSG-PATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPPP 84

Human   144 Y---------QPI--YPQSQDPYSHV-NDPYS--LNPLHAQPQPQHPGWPGQRQSQES-GLLHTH 193
            :         |.|  |.|:.....:: .|||.  |:.||..|...:....|.|.:|:. |:..||
  Fly    85 FHHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTH 149

Human   194 R---------GLPHQLSGLDPRRDYRRHEDLLHGPHALSSG------LG----DLSIH-SLPHAI 238
            |         .|.|.....|.|.||         ..|:|:|      ||    .|::| :|.:|:
  Fly   150 REAELQGHVTQLSHGFPYTDRRSDY---------GSAISAGAAHGTRLGHEHESLALHQALQNAV 205

Human   239 EEV--PHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLS 301
            ::|  |.::|....:.|..:||.     .||...|        .|:..|  :|:||||:||||||
  Fly   206 DDVQAPALDDNVAFMSDLPLIKS-----MKSGKEA--------GNIGSG--SPSEVFCAVPGRLS 255

Human   302 LLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAA 366
            |||||||||||:||||||||||||||||||||||||||||||||.|||||:||||||||||||||
  Fly   256 LLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAA 320

Human   367 NVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFT 431
            |||||||||||||.|||:||.:||||||||:.:||::.|..::|.:...||.::|.::||.||..
  Fly   321 NVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELM 385

Human   432 DLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYL 496
            .:|:|||:....:|...:|||.:|..||||:||:|||||||:.|.:.|.|.:|.|:|..::|:|.
  Fly   386 QILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYP 450

Human   497 SNNPNSHTDNNAKSS-DKEEK 516
            ||.....:.:..||. |.|:|
  Fly   451 SNGGGMVSSSLDKSKIDNEKK 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TFAP2A	XP_016866721.1	None
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	133/193 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160186
Domainoid	1	1.000	277	1.000	Domainoid score	I1732
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2421
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2522
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm40888
orthoMCL	1	0.900	-	-		OOG6_105211
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930