DRSC/TRiP Functional Genomics Resources

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Protein Alignment TESK1 and HRR25

DIOPT Version :10

Sequence 1:NP_006276.2 Gene:TESK1 / 7016 HGNCID:11731 Length:626 Species:Homo sapiens
Sequence 2:NP_015120.1 Gene:HRR25 / 855897 SGDID:S000006125 Length:494 Species:Saccharomyces cerevisiae


Alignment Length:547 Identity:116/547 - (21%)
Similarity:195/547 - (35%) Gaps:141/547 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    57 FHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNI--------- 112
            |....|||:|.|.::|...:..||:.:.:|:..:               |.|||.:         
Yeast     9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESI---------------RSRHPQLDYESRVYRY 58

Human   113 ---------LRFMGVCVHQGQLHALTEYMNGGTLEQLLS-SPEPLSWPVRLHLALDIARGLRYLH 167
                     :|:.|   .:|:.:|:...:.|.:||.|.: .....|:...:.|||.:...::|:|
Yeast    59 LSGGVGIPFIRWFG---REGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIH 120

Human   168 SKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEK---------IPVYREGARKEPLAVVGSPYW 223
            .:...|||:...|.|:....||.|..|.||||::|         || |||..     ::.|:..:
Yeast   121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP-YRENK-----SLTGTARY 179

Human   224 MAPEVLRGELYDEKADVFAFGIVLCELI--------ARVPADPDYLPRTEDFGLDVPAFRTLVGD 280
            .:.....|.....:.|:.:.|.||....        .:.........|..:..|:| :..||. .
Yeast   180 ASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNV-SVETLC-S 242

Human   281 DCPLPFLLLAIHCCNLEPSTRAP-------FTEITQHLEWILEQLPEPAPLTRTALTHNQGSVAR 338
            ..||.|.....:|.||:...:..       |.:::..||:..:.|     ...|.|.:.:..|.:
Yeast   243 GLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHL-----FDWTMLRYTKAMVEK 302

Human   339 GGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVL 403
                      ...|...:.||....:..|..|..||  :...|:        |||||      .:
Yeast   303 ----------QRDLLIEKGDLNANSNAASASNSTDN--KSETFN--------KIKLL------AM 341

Human   404 PLVP-------------PSPFPSTQLPLV------TTPETL----------VQPGTPARRCRSLP 439
            ...|             |||....|..::      :.||.|          ::...|.::.:|..
Yeast   342 KKFPTHFHYYKNEDKHNPSPEEIKQQTILNNNAASSLPEELLNALDKGMENLRQQQPQQQVQSSQ 406

Human   440 SSPELPRRMETALPGPGP---PAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSS 501
            ..|: |::::....|..|   |......:::...|.....|.....|.|.|..:.::||  ..:.
Yeast   407 PQPQ-PQQLQQQPNGQRPNYYPEPLLQQQQRDSQEQQQQVPMATTRATQYPPQINSNNF--NTNQ 468

Human   502 ASQPWSPRSGPVLNNNPPAVVVNSPQG 528
            ||.|...||.|   ..||.   :.|.|
Yeast   469 ASVPPQMRSNP---QQPPQ---DKPAG 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TESK1NP_006276.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
PKc_TESK 63..318 CDD:271057 65/297 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..373 6/41 (15%)
Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572 419..524 25/123 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..488 13/77 (17%)
Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572 527..626 1/2 (50%)
Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572 527..624 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..564 116/547 (21%)
HRR25NP_015120.1 Protein Kinases, catalytic domain 8..282 CDD:473864 66/298 (22%)
Blue background indicates that the domain is not in the aligned region.

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