Protein Alignment TESK1 and tesk1a

DIOPT Version :10

• Sequence 1: NP_006276.2
• Gene: TESK1 / 7016
• HGNCID: 11731
• Length: 626
• Species: Homo sapiens
• Sequence 2: XP_021332499.1
• Gene: tesk1a / 556048
• ZFINID: ZDB-GENE-090312-74
• Length: 657
• Species: Danio rerio
• Alignment Length: 675
• Identity: 329/675 - (48%)
• Similarity: 392/675 - (58%)
• Gaps: 116/675 - (17%)

Human    32 GPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGN 96
            ||.|.|||||||||||||||||:|||.| ||||:||||||:||:||.:||||.||||.|.||:.|
Zfish    19 GPNRIRPSSYRALRSAVSSLARIDDFFC-EKIGSGFFSEVFKVQHRITGQVMALKMNTLASNKAN 82

Human    97 TLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAR 161
            .||||||||||.|||||||:|||||:|||||||||:|||.|||||.|...|||.||:.|:|||||
Zfish    83 MLREVQLMNRLCHPNILRFLGVCVHEGQLHALTEYINGGNLEQLLDSDIYLSWTVRIGLSLDIAR 147

Human   162 GLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAP 226
            ||:||||||:|||||||||||||.|:..|||||||||||||||.|.:|..|:|||||||||||||
Zfish   148 GLQYLHSKGIFHRDLTSKNCLVRCENGAFTAVVGDFGLAEKIPDYSDGVEKQPLAVVGSPYWMAP 212

Human   227 EVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAI 291
            |:||||||:||.||||:||:|||:|||:.||||.|||||||||||..|..:|| |||..||.:|:
Zfish   213 EMLRGELYNEKVDVFAYGIILCEIIARIEADPDILPRTEDFGLDVDTFEHMVG-DCPPSFLQMAV 276

Human   292 HCCNLEPSTRAPFTEITQHLEWI-LEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRS 355
            .|||:...:|..|:||...||.| .|::....|:....:..:.....|  .|:.....|.|||||
Zfish   277 DCCNMNADSRPAFSEIVVMLERIERERVKSEIPVILEPIAIDVSPYRR--RSSPCHPCDQRLSRS 339

Human   356 RSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPL---VPPSPFPSTQLP 417
            :||: |||:  :.|..| ...||||||||:||.||:|||.|||||.|:.|   :||.|.||...|
Zfish   340 QSDM-LPPA--TSPCLG-TPARVNPFSLRQDLNGGRIKLFDTPSKSVISLTFTLPPPPDPSASPP 400

Human   418 LVTTPETLVQPGT--PARRCRSLPSSPELPRRM--------------------ETALPGPGPPAV 460
            |..:      ||.  |.|||||||.:|||.|::                    :..|.|. ..||
Zfish   401 LSGS------PGLRGPPRRCRSLPCTPELGRQLPFRDQEVEEDRSEELGQETKDKELEGQ-QDAV 458

Human   461 GPSA------------------EEKMECEGSS-PEPEPPGPAPQLPLAVATDNFIS--------- 497
            ..|.                  :|::|.||.| .||.....:|.     .|:..:|
Zfish   459 EDSGLVLDLDMVSLERVEEEEEDEEVEKEGQSLTEPMDCSSSPD-----TTEGNVSGKRLISGSS 518

Human   498 -TCSSASQPW-SPRSG--------PVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEP 552
             :.|..|..| :|.|.        |.|:||...:....|..|......|.              |
Zfish   519 YSSSLQSNGWATPISNGPPLLPPLPRLDNNNGVLRPGRPFAWVRLNGYRG--------------P 569

Human   553 SPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVAR------YRNLN------CEAGSLL 605
            :|.|..|.|.|:.:.||.|||..|||.  |:|.|..|...|      ||..|      ..|..||
Zfish   570 APEPLPPTEQDDVISCPACCLAGFSFP--SLCLRGAPPSRRGPPRRPYRTFNGGDASTATAKGLL 632

Human   606 CHRGHHAKPPT----PSLQLPGARS 626
            |.......|.|    |.|.||.|::
Zfish   633 CRGATGLAPSTASCEPGLPLPEAQT 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		6/8 (75%)
		PKc_TESK	63..318	CDD:271057	184/255 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..373		14/41 (34%)
		Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572	419..524		38/164 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..488		27/105 (26%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572	527..626		35/114 (31%)
		Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572	527..624		34/112 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..564		7/34 (21%)
tesk1a	XP_021332499.1	PKc_TESK	49..303	CDD:271057	183/254 (72%)