Protein Alignment TESK1 and Tesk1

DIOPT Version :10

• Sequence 1: NP_006276.2
• Gene: TESK1 / 7016
• HGNCID: 11731
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_113766.1
• Gene: Tesk1 / 29460
• RGDID: 62059
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 578/633 - (91%)
• Similarity: 591/633 - (93%)
• Gaps: 12/633 - (1%)

Human     1 MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGA 65
            |||||||||  ||||||.|.|   ||||.||||||||||||||||||||||||||||.|||||||
  Rat     1 MAGERPPLR--GPGPGETPVE---GPGGAGGGPGRGRPSSYRALRSAVSSLARVDDFDCAEKIGA 60

Human    66 GFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTE 130
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat    61 GFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTE 125

Human   131 YMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVG 195
            ||||||||||||||||||||||||||||||:||||||:|||||||||||||||||||.|||||||
  Rat   126 YMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDGGFTAVVG 190

Human   196 DFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDY 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   191 DFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDY 255

Human   261 LPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPA--- 322
            |||||||||||||||||||:||||||||||||||::|||.||||||||||||.||||||||.
  Rat   256 LPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLPEPTPLA 320

Human   323 --PLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLRE 385
              ||.:..||:|||||.||||||||||.|||||||||||||||||||||:|||||||||||||||
  Rat   321 KMPLAKAPLTYNQGSVPRGGPSATLPRSDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLRE 385

Human   386 DLRGGKIKLLDTPSKPV--LPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRM 448
            |||||||||||||.||.  ||||||||..|||||||.:||:||||.||.||||||||||||||||
  Rat   386 DLRGGKIKLLDTPCKPATPLPLVPPSPLTSTQLPLVASPESLVQPETPVRRCRSLPSSPELPRRM 450

Human   449 ETALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPV 513
            |||||||||..||||.||:|:||||||||||||||||||||||||||||||||||||||.|.||.
  Rat   451 ETALPGPGPSPVGPSTEERMDCEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSARPGPS 515

Human   514 LNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSF 578
            |||||||||||||||||.||||||||||||||||||||||||||||||.:||||||||||.||||
  Rat   516 LNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREQEEGLPCPGCCLSPFSF 580

Human   579 GFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS 626
            ||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   581 GFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		31/39 (79%)
		PKc_TESK	63..318	CDD:271057	245/254 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..373		37/41 (90%)
		Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572	419..524		91/104 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..488		56/64 (88%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572	527..626		94/98 (96%)
		Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572	527..624		92/96 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..564		32/34 (94%)
Tesk1	NP_113766.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		30/38 (79%)
		PKc_TESK	58..313	CDD:271057	245/254 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..376		41/45 (91%)
		Required for interaction with YWHAB. /evidence=ECO:0000269|PubMed:11555644	421..526		91/104 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..490		57/65 (88%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000269|PubMed:17974561	529..628		94/98 (96%)
		Required for interaction with PARVA. /evidence=ECO:0000269|PubMed:15817463	529..626		92/96 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..568		27/29 (93%)