Protein Alignment TESK1 and Y105C5A.24

DIOPT Version :10

• Sequence 1: NP_006276.2
• Gene: TESK1 / 7016
• HGNCID: 11731
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_502888.2
• Gene: Y105C5A.24 / 190882
• WormBaseID: WBGene00013643
• Length: 478
• Species: Caenorhabditis elegans
• Alignment Length: 496
• Identity: 117/496 - (23%)
• Similarity: 181/496 - (36%)
• Gaps: 132/496 - (26%)

Human    15 PGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDF-----HCAEK-----IGAGFFS 69
            |......|||.            |...|..|.  |.|....|.     :|.::     :|.|.|.
 Worm     5 PSSSSSTGPPA------------PVIQRKTRD--SDLCLTSDIPKIPPNCIDELNSHFLGKGTFG 55

Human    70 EVYKVRHRQ---------------SGQVMVLKMNKLPSNRGNTLREVQLMNRLR-HPNILRFMGV 118
            .|.|.::|:               :..:.:||            ||.:.|..|| |.||::..|:
 Worm    56 VVEKTKYRKTRDDTYRPAAIKYASATHLSILK------------REAKHMWNLRNHVNIIKIYGM 108

Human   119 C-VHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLA---LDIARGLRYLHSKGVFHRDLTSK 179
            . .|:.....:.|||:.|.:..|:...:.:.:.:. |:|   ..::..:.:.|||...||||..:
 Worm   109 YESHRNGQGLVMEYMDCGCVADLIYDRKNIEYKMD-HVASWMYQLSSAVNFFHSKDQIHRDLKLQ 172

Human   180 NCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFG 244
            |.|:....|  |..:.|||....|.......|       |||..||||:.|.|.|:.|||:|:.|
 Worm   173 NMLLSHHHR--TLKICDFGTFTSIHQSMTSNR-------GSPITMAPEIFRCEPYNMKADIFSIG 228

Human   245 IVLCELIARVPADPDY---LPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIH--CCNLEPSTRAPF 304
            |::.::|||   |..|   :|.| .|..:| |.|.|...:.....:|...:  |.:..|::|...
 Worm   229 IIMWQMIAR---DHPYTMNMPIT-PFLYNV-ATRNLRPHEIECNPILSNFYKRCWSDNPASRPTS 288

Human   305 TEITQHLEWILEQLPE-PAPLTRTALTHNQGSVARGGPSAT--LPRPDPRLSRSRSDLFLPPSPE 366
            .:..::...:..:.|. ..||...|          .|.|.|  :|:..|   ..||.|.||.
 Worm   289 ADCVEYFRCLRSEYPNGNVPLWDPA----------SGASNTVKIPKSQP---GGRSPLPLPK--- 337

Human   367 SPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPL-VPPSPFPSTQLPLVTTPETLVQPGT 430
                     |.:.|               |...|.|.|. |..:|        ...|:||..|..
 Worm   338 ---------TEITP---------------DVKPKEVAPAKVQETP--------ALLPDTLKVPKV 370

Human   431 PARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECE 471
            .    |.:.:..|..:...|||.......:.|:..::...|
 Worm   371 E----RQISNEEEKQKIFMTALSNEDTRPIDPNEGDESSLE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		5/25 (20%)
		PKc_TESK	63..318	CDD:271057	73/279 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..373		10/43 (23%)
		Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572	419..524		11/53 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..488		10/49 (20%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572	527..626
		Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572	527..624
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..564
Y105C5A.24	NP_502888.2	Protein Kinases, catalytic domain	49..287	CDD:473864	73/264 (28%)