DRSC/TRiP Functional Genomics Resources

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Protein Alignment TESK1 and K09B11.5

DIOPT Version :10

Sequence 1:NP_006276.2 Gene:TESK1 / 7016 HGNCID:11731 Length:626 Species:Homo sapiens
Sequence 2:NP_001040971.1 Gene:K09B11.5 / 178307 WormBaseID:WBGene00010712 Length:589 Species:Caenorhabditis elegans


Alignment Length:473 Identity:124/473 - (26%)
Similarity:185/473 - (39%) Gaps:117/473 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    58 HCAEKIGAGFFSEVYKVR-----HRQSGQVMVLKMNKLPSNRGNTLR--------EVQLMNRLRH 109
            |....:|.|.|.||.|.|     |....:|.|.::      .|...|        |.|:|..|:|
 Worm   182 HLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRV------IGTAQREQMQEFCHEAQIMGTLKH 240

Human   110 PNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHR 174
            .|:::..|:...:..:..:.|.:.||.|::.|.|...:.....:..|||||.|:|:|..|.|.||
 Worm   241 DNVVKLYGIASLEQPIMLVMELITGGDLKKYLQSTPSIPNRQLIAFALDIANGMRHLVIKKVIHR 305

Human   175 DLTSKNCLVRREDRGFTAVVGDFGLA-EKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKA 238
            ||.::|||:.|..  ....:.||||| :...|..:...|.|..      |:|||..:..:::||.
 Worm   306 DLAARNCLISRPT--LQVKISDFGLAVQATEVIVKKLSKAPTR------WLAPETFQKGIFNEKT 362

Human   239 DVFAFGIVLCELIARVPADPDYLPRT----EDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPS 299
            ||::||:||.|::.|..||| ..|||    :.:.::.|....:...: |.....|...||:....
 Worm   363 DVWSFGVVLTEILTRCAADP-LAPRTLEECKKYIIESPHPHRIENKE-PKELAELVEMCCDKNTM 425

Human   300 TRAPFTEITQHLEWILEQLPEP----------APLTRTALTHNQGSVAR-----GGPSATLPRPD 349
            .||.|....:.|:.:::|...|          ....|..:..:..:|.|     ||..|::.|. 
 Worm   426 CRANFQNAKRRLKIVIDQYDHPDGHKLELKKSEEQKRLTIRRSTATVTRKKSRDGGRQASVERK- 489

Human   350 PRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKL-------LDTPSKP------ 401
                                  |....|.....||:|  .|.:||       |:.||.|      
 Worm   490 ----------------------GHGTQRKVVSVLRKD--KGALKLPSGIATNLERPSPPSHTAKS 530

Human   402 ---VLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLP--SSPELPRRMETALPGPGPPAVG 461
               ..|:.||...|....|.|:.| .:.||..      |.|  |.|.:|:.     |...|||  
 Worm   531 HTVKSPMTPPVSQPPVSQPPVSQP-PVSQPPV------SQPPVSQPPVPQH-----PMTPPPA-- 581

Human   462 PSAEEKMECEGSSPEPEP 479
                       ||..|.|
 Worm   582 -----------SSARPHP 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TESK1NP_006276.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
PKc_TESK 63..318 CDD:271057 80/272 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..373 6/46 (13%)
Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572 419..524 17/63 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..488 15/59 (25%)
Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572 527..626
Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572 527..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..564
K09B11.5NP_001040971.1 SH2 74..160 CDD:214585
TyrKc 181..437 CDD:197581 80/270 (30%)
Blue background indicates that the domain is not in the aligned region.

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