Protein Alignment TESK1 and lin-45

DIOPT Version :10

• Sequence 1: NP_006276.2
• Gene: TESK1 / 7016
• HGNCID: 11731
• Length: 626
• Species: Homo sapiens
• Sequence 2: NP_001379593.1
• Gene: lin-45 / 177436
• WormBaseID: WBGene00003030
• Length: 855
• Species: Caenorhabditis elegans
• Alignment Length: 405
• Identity: 104/405 - (25%)
• Similarity: 164/405 - (40%)
• Gaps: 86/405 - (21%)

Human     6 PPLRGP----GPG--------PGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFH 58
            ||...|    .||        |||......|.|      |.:.....:..|         .::|.
 Worm   475 PPQSAPPQKISPGFFRNRSRSPGERLDAQRPRP------PQKPHHEDWEIL---------PNEFI 524

Human    59 CAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKL---PSNRGNTLREVQLMNRLRHPNILRFMGVCV 120
            ...|:|:|.|..||  |....|.|.:.|:|.:   ||.......||.::.:.||.|:|.||| .|
 Worm   525 IQYKVGSGSFGTVY--RGEFFGTVAIKKLNVVDPTPSQMAAFKNEVAVLKKTRHLNVLLFMG-WV 586

Human   121 HQGQLHALTEYMNGGTLEQLLSSPEP---LSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCL 182
            .:.::..:|::..|.:|.:.:...||   ......:.:...::.|:.|||||.:.||||.:.|..
 Worm   587 REPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIF 651

Human   183 VRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLR---GELYDEKADVFAFG 244
            :.  |...|..:||||||.....:.....::.....||..||||||:|   ...|..::||::||
 Worm   652 LM--DDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRMQDDNPYTPQSDVYSFG 714

Human   245 IVLCELIARVPADPDYLPRTEDFGLDVPAF----------RTLVGDDCPLPFLLLAIHCCNLEPS 299
            |.:.|:::      .:||.:.....|...|          |:.:..|.|...|.|..:|...:.:
 Worm   715 ICMYEILS------SHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKLYDNCIMFDRN 773

Human   300 TRAPFTEITQHLEWILEQLPEPAPLTRTALTHN----------QGSVARGGPSATLPRPDPRLSR 354
            .|..|.|:.:.|..|:  ||:   |||:....|          ..:|.|              |:
 Worm   774 ERPVFGEVLERLRDII--LPK---LTRSQSAPNVLHLDSQYSVMDAVMR--------------SQ 819

Human   355 SRSDLFLPPSPESPP 369
            ..|..::||:....|
 Worm   820 MLSWSYIPPATAKTP 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		11/46 (24%)
		PKc_TESK	63..318	CDD:271057	77/273 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..373		8/49 (16%)
		Required for interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q63572	419..524
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..488
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250|UniProtKB:Q63572	527..626
		Required for interaction with PARVA. /evidence=ECO:0000250|UniProtKB:Q63572	527..624
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..564
lin-45	NP_001379593.1	RBD	128..203	CDD:128731
		C1_Raf	211..260	CDD:410361
		STKc_Raf	529..786	CDD:270964	75/267 (28%)